Severe asthma: Lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

Nizar N. Jarjour, Serpil C. Erzurum, Eugene R. Bleecker, William J. Calhoun, Mario Castro, Suzy A.A. Comhair, Kian Fan Chung, Douglas Curran-Everett, Raed A. Dweik, Sean B. Fain, Anne M. Fitzpatrick, Benjamin M. Gaston, Elliot Israel, Annette Hastie, Eric A. Hoffman, Fernando Holguin, Bruce D. Levy, Deborah A. Meyers, Wendy C. Moore, Stephen P. PetersRonald L. Sorkness, W. Gerald Teague, Sally E. Wenzel, William W. Busse

Research output: Contribution to journalReview article

158 Scopus citations

Abstract

The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, andcellular inflammatory features anduniquestructure-function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.

Original languageEnglish (US)
Pages (from-to)356-362
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume185
Issue number4
DOIs
StatePublished - Feb 15 2012

Keywords

  • Asthma
  • Bronchoscopy
  • Imaging
  • Inflammation
  • Remodeling

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Jarjour, N. N., Erzurum, S. C., Bleecker, E. R., Calhoun, W. J., Castro, M., Comhair, S. A. A., Chung, K. F., Curran-Everett, D., Dweik, R. A., Fain, S. B., Fitzpatrick, A. M., Gaston, B. M., Israel, E., Hastie, A., Hoffman, E. A., Holguin, F., Levy, B. D., Meyers, D. A., Moore, W. C., ... Busse, W. W. (2012). Severe asthma: Lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. American Journal of Respiratory and Critical Care Medicine, 185(4), 356-362. https://doi.org/10.1164/rccm.201107-1317PP