Severe cholestatic jaundice associated with piroxicam

Kenneth S. Hepps, George M. Maliha, Rolando Estrada, Richard W. Goodgame

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities normalized 4 months after he discontinued taking piroxicam. This is the first case report in the United States of severe liver toxicity associated with piroxicam. The six cases in the English-language literature are reviewed, featuring the presentation, patterns of liver injury, and outcome in each. Piroxicam should be considered as a potential cause of cholestatic jaundice when other more common etiologies have been excluded.

Original languageEnglish (US)
Pages (from-to)1737-1740
Number of pages4
JournalGastroenterology
Volume101
Issue number6
DOIs
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Hepps, K. S., Maliha, G. M., Estrada, R., & Goodgame, R. W. (1991). Severe cholestatic jaundice associated with piroxicam. Gastroenterology, 101(6), 1737-1740. https://doi.org/10.1016/0016-5085(91)90417-J