Severe cholestatic jaundice associated with piroxicam

Kenneth S. Hepps, George M. Maliha, Rolando Estrada, Richard W. Goodgame

Research output: Contribution to journalArticle

20 Scopus citations


A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities normalized 4 months after he discontinued taking piroxicam. This is the first case report in the United States of severe liver toxicity associated with piroxicam. The six cases in the English-language literature are reviewed, featuring the presentation, patterns of liver injury, and outcome in each. Piroxicam should be considered as a potential cause of cholestatic jaundice when other more common etiologies have been excluded.

Original languageEnglish (US)
Pages (from-to)1737-1740
Number of pages4
Issue number6
StatePublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepps, K. S., Maliha, G. M., Estrada, R., & Goodgame, R. W. (1991). Severe cholestatic jaundice associated with piroxicam. Gastroenterology, 101(6), 1737-1740.