Severe radiation therapy-related soft tissue toxicity in a patient with porphyria cutanea tarda

A literature review

G. Brandon Gunn, Karl Anderson, Abhilasha J. Patel, Juan Gallegos, Csilla Kormos Hallberg, Gagan Sood, Sandra Hatch, Giuseppe Sanguineti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Some porphyrias are associated with cutaneous phototoxicity due to photoactivation of porphyrins, but whether ionizing radiation can have an additive effect is not clear. We report a case of severe radiation therapy-related toxicity in a patient with porphyria cutanea tarda and review the literature. Methods. A 50-year-old man with porphyria cutanea was treated for lower lip squamous cell carcinoma with definitive radiation therapy. During radiation therapy, acute toxicity was of an expected onset and severity. Six months after treatment completion, he developed skin hypopigmentation, soft tissue fibrosis, and areas of painful denuded skin and crusting within the previous treatment field. Results. Reports of 7 patients with porphyria receiving radiation therapy to at least 9 separate sites were reviewed, with only 1 previous report suggestive of increased radiation therapy-related toxicity. Conclusion. Based on this and 1 other report, caution is warranted when considering radiation therapy in patients with active porphyria.

Original languageEnglish (US)
Pages (from-to)1112-1117
Number of pages6
JournalHead and Neck
Volume32
Issue number8
DOIs
StatePublished - Aug 2010

Fingerprint

Porphyria Cutanea Tarda
Porphyrias
Radiotherapy
Skin
Hypopigmentation
Phototoxic Dermatitis
Porphyrins
Lip
Ionizing Radiation
Squamous Cell Carcinoma
Fibrosis
Therapeutics

Keywords

  • Cancer
  • Porphyria
  • Radiation therapy
  • Toxicity

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Severe radiation therapy-related soft tissue toxicity in a patient with porphyria cutanea tarda : A literature review. / Gunn, G. Brandon; Anderson, Karl; Patel, Abhilasha J.; Gallegos, Juan; Hallberg, Csilla Kormos; Sood, Gagan; Hatch, Sandra; Sanguineti, Giuseppe.

In: Head and Neck, Vol. 32, No. 8, 08.2010, p. 1112-1117.

Research output: Contribution to journalArticle

Gunn, G. Brandon ; Anderson, Karl ; Patel, Abhilasha J. ; Gallegos, Juan ; Hallberg, Csilla Kormos ; Sood, Gagan ; Hatch, Sandra ; Sanguineti, Giuseppe. / Severe radiation therapy-related soft tissue toxicity in a patient with porphyria cutanea tarda : A literature review. In: Head and Neck. 2010 ; Vol. 32, No. 8. pp. 1112-1117.
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