Severe sepsis during pregnancy

Luis D. Pacheco, George R. Saade, Gary D.V. Hankins

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Severe sepsis is a major cause of mortality among critically ill patients. Early recognition accompanied by early initiation of broad-spectrum antibiotics with source control and fluid resuscitation improves outcomes. Hemodynamic resuscitation starts with fluid therapy followed by vasopressors if necessary. Cases refractory to first-line vasopressors (norepinephrine) will require second-line vasopressors (epinephrine or vasopressin) and low-dose steroid therapy. Resuscitation goals should include optimization of central venous oxygenation and serum lactate.

Original languageEnglish (US)
Pages (from-to)827-834
Number of pages8
JournalClinical Obstetrics and Gynecology
Issue number4
StatePublished - 2014


  • Pregnancy
  • Sepsis
  • Septic shock

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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