Severe serum sickness after H1N1 influenza vaccination

Rana S. Bonds, Brent Kelly

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study, the case of a 48-year-old man with severe serum sickness reaction in response to H1N1 influenza immunization is reported. He presented with renal failure and several of the classic signs reported in early descriptions of serum sickness by Clemens von Pirquet and Bela Schick including lymphadenopathy, urticarial skin eruption and facial edema. Serum immunologic studies and tissue histology/immunohistochemistry assisted in firmly establishing the diagnosis in this case. With appropriate therapy, the patient's rash, edema and lymphadenopathy resolved and normal renal function returned. This first reported case of severe serum sickness to H1N1 vaccine is particularly important in light of the Centers for Disease Control and Prevention's recommendation for universal vaccination against influenza, including H1N1, in patients 6 months and older. With increasing numbers of patients receiving this vaccine, even rare adverse reactions may be experienced by numerous individuals. It is imperative that clinicians remain vigilant about possible reactions and quickly institute appropriate therapy.

Original languageEnglish (US)
Pages (from-to)412-413
Number of pages2
JournalAmerican Journal of the Medical Sciences
Volume345
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Serum Sickness
Human Influenza
Vaccination
Edema
Vaccines
Centers for Disease Control and Prevention (U.S.)
Exanthema
Renal Insufficiency
Immunization
Histology
Immunohistochemistry
Kidney
Skin
Therapeutics
Serum
Lymphadenopathy

Keywords

  • Influenza
  • Serum sickness
  • Vaccination
  • Vaccine reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Severe serum sickness after H1N1 influenza vaccination. / Bonds, Rana S.; Kelly, Brent.

In: American Journal of the Medical Sciences, Vol. 345, No. 5, 05.2013, p. 412-413.

Research output: Contribution to journalArticle

@article{5a339f5f994845b1b5a42f6a150019cf,
title = "Severe serum sickness after H1N1 influenza vaccination",
abstract = "In this study, the case of a 48-year-old man with severe serum sickness reaction in response to H1N1 influenza immunization is reported. He presented with renal failure and several of the classic signs reported in early descriptions of serum sickness by Clemens von Pirquet and Bela Schick including lymphadenopathy, urticarial skin eruption and facial edema. Serum immunologic studies and tissue histology/immunohistochemistry assisted in firmly establishing the diagnosis in this case. With appropriate therapy, the patient's rash, edema and lymphadenopathy resolved and normal renal function returned. This first reported case of severe serum sickness to H1N1 vaccine is particularly important in light of the Centers for Disease Control and Prevention's recommendation for universal vaccination against influenza, including H1N1, in patients 6 months and older. With increasing numbers of patients receiving this vaccine, even rare adverse reactions may be experienced by numerous individuals. It is imperative that clinicians remain vigilant about possible reactions and quickly institute appropriate therapy.",
keywords = "Influenza, Serum sickness, Vaccination, Vaccine reaction",
author = "Bonds, {Rana S.} and Brent Kelly",
year = "2013",
month = "5",
doi = "10.1097/MAJ.0b013e318273de7f",
language = "English (US)",
volume = "345",
pages = "412--413",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Severe serum sickness after H1N1 influenza vaccination

AU - Bonds, Rana S.

AU - Kelly, Brent

PY - 2013/5

Y1 - 2013/5

N2 - In this study, the case of a 48-year-old man with severe serum sickness reaction in response to H1N1 influenza immunization is reported. He presented with renal failure and several of the classic signs reported in early descriptions of serum sickness by Clemens von Pirquet and Bela Schick including lymphadenopathy, urticarial skin eruption and facial edema. Serum immunologic studies and tissue histology/immunohistochemistry assisted in firmly establishing the diagnosis in this case. With appropriate therapy, the patient's rash, edema and lymphadenopathy resolved and normal renal function returned. This first reported case of severe serum sickness to H1N1 vaccine is particularly important in light of the Centers for Disease Control and Prevention's recommendation for universal vaccination against influenza, including H1N1, in patients 6 months and older. With increasing numbers of patients receiving this vaccine, even rare adverse reactions may be experienced by numerous individuals. It is imperative that clinicians remain vigilant about possible reactions and quickly institute appropriate therapy.

AB - In this study, the case of a 48-year-old man with severe serum sickness reaction in response to H1N1 influenza immunization is reported. He presented with renal failure and several of the classic signs reported in early descriptions of serum sickness by Clemens von Pirquet and Bela Schick including lymphadenopathy, urticarial skin eruption and facial edema. Serum immunologic studies and tissue histology/immunohistochemistry assisted in firmly establishing the diagnosis in this case. With appropriate therapy, the patient's rash, edema and lymphadenopathy resolved and normal renal function returned. This first reported case of severe serum sickness to H1N1 vaccine is particularly important in light of the Centers for Disease Control and Prevention's recommendation for universal vaccination against influenza, including H1N1, in patients 6 months and older. With increasing numbers of patients receiving this vaccine, even rare adverse reactions may be experienced by numerous individuals. It is imperative that clinicians remain vigilant about possible reactions and quickly institute appropriate therapy.

KW - Influenza

KW - Serum sickness

KW - Vaccination

KW - Vaccine reaction

UR - http://www.scopus.com/inward/record.url?scp=84876843956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876843956&partnerID=8YFLogxK

U2 - 10.1097/MAJ.0b013e318273de7f

DO - 10.1097/MAJ.0b013e318273de7f

M3 - Article

C2 - 23221512

AN - SCOPUS:84876843956

VL - 345

SP - 412

EP - 413

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 5

ER -