Abstract
Two-thirds of Americans with Alzheimer’s disease are women, indicating a profound variance between the sexes. Variances exist between the sexes in the age and intensity of the presentation, cognitive deficits, neuroinflammatory factors, structural and functional brain changes, as well as psychosocial and cultural circumstances. Herein, we summarize the existing evidence for sexual dimorphism and present the available evidence for these distinctions. Understanding these complexities is critical to developing personalized interventions for the prevention, care, and treatment of Alzheimer’s disease.
Original language | English (US) |
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Article number | 8485 |
Journal | International journal of molecular sciences |
Volume | 25 |
Issue number | 15 |
DOIs | |
State | Published - Aug 2024 |
Externally published | Yes |
Keywords
- Alzheimer’s disease
- neuroinflammation
- personalized medicine
- risk factors
- sex differences
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry