Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila

Valbona Hoxha, Chamala Lama, Peter L. Chang, Sumit Saurabh, Naiya Patel, Nicole Olate, Brigitte Dauwalder

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.

Original languageEnglish (US)
Article numbere1003217
JournalPLoS Genetics
Volume9
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Courtship
blood-brain barrier
courtship
Blood-Brain Barrier
Drosophila
brain
blood
gender
mating behavior
Feminization
feminization
Sex Factors
male behavior
protein
G-Protein-Coupled Receptors
Drosophila melanogaster
Brain

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Hoxha, V., Lama, C., Chang, P. L., Saurabh, S., Patel, N., Olate, N., & Dauwalder, B. (2013). Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila. PLoS Genetics, 9(1), [e1003217]. https://doi.org/10.1371/journal.pgen.1003217

Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila. / Hoxha, Valbona; Lama, Chamala; Chang, Peter L.; Saurabh, Sumit; Patel, Naiya; Olate, Nicole; Dauwalder, Brigitte.

In: PLoS Genetics, Vol. 9, No. 1, e1003217, 01.2013.

Research output: Contribution to journalArticle

Hoxha, V, Lama, C, Chang, PL, Saurabh, S, Patel, N, Olate, N & Dauwalder, B 2013, 'Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila', PLoS Genetics, vol. 9, no. 1, e1003217. https://doi.org/10.1371/journal.pgen.1003217
Hoxha, Valbona ; Lama, Chamala ; Chang, Peter L. ; Saurabh, Sumit ; Patel, Naiya ; Olate, Nicole ; Dauwalder, Brigitte. / Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila. In: PLoS Genetics. 2013 ; Vol. 9, No. 1.
@article{90e724008f2b4c1f839e18a6a0f3f1de,
title = "Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila",
abstract = "Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.",
author = "Valbona Hoxha and Chamala Lama and Chang, {Peter L.} and Sumit Saurabh and Naiya Patel and Nicole Olate and Brigitte Dauwalder",
year = "2013",
month = "1",
doi = "10.1371/journal.pgen.1003217",
language = "English (US)",
volume = "9",
journal = "PLoS Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "1",

}

TY - JOUR

T1 - Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila

AU - Hoxha, Valbona

AU - Lama, Chamala

AU - Chang, Peter L.

AU - Saurabh, Sumit

AU - Patel, Naiya

AU - Olate, Nicole

AU - Dauwalder, Brigitte

PY - 2013/1

Y1 - 2013/1

N2 - Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.

AB - Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.

UR - http://www.scopus.com/inward/record.url?scp=84873494782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873494782&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.1003217

DO - 10.1371/journal.pgen.1003217

M3 - Article

VL - 9

JO - PLoS Genetics

JF - PLoS Genetics

SN - 1553-7390

IS - 1

M1 - e1003217

ER -