Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila

Valbona Hoxha, Chamala Lama, Peter L. Chang, Sumit Saurabh, Naiya Patel, Nicole Olate, Brigitte Dauwalder

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.

Original languageEnglish (US)
Article numbere1003217
JournalPLoS genetics
Volume9
Issue number1
DOIs
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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    Hoxha, V., Lama, C., Chang, P. L., Saurabh, S., Patel, N., Olate, N., & Dauwalder, B. (2013). Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila. PLoS genetics, 9(1), [e1003217]. https://doi.org/10.1371/journal.pgen.1003217