Abstract
Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.
| Original language | English (US) |
|---|---|
| Article number | e1003217 |
| Journal | PLoS Genetics |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Ecology, Evolution, Behavior and Systematics
- Cancer Research
- Genetics(clinical)
Cite this
Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila. / Hoxha, Valbona; Lama, Chamala; Chang, Peter L.; Saurabh, Sumit; Patel, Naiya; Olate, Nicole; Dauwalder, Brigitte.
In: PLoS Genetics, Vol. 9, No. 1, e1003217, 01.2013.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila
AU - Hoxha, Valbona
AU - Lama, Chamala
AU - Chang, Peter L.
AU - Saurabh, Sumit
AU - Patel, Naiya
AU - Olate, Nicole
AU - Dauwalder, Brigitte
PY - 2013/1
Y1 - 2013/1
N2 - Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.
AB - Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior.
UR - http://www.scopus.com/inward/record.url?scp=84873494782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873494782&partnerID=8YFLogxK
U2 - 10.1371/journal.pgen.1003217
DO - 10.1371/journal.pgen.1003217
M3 - Article
C2 - 23359644
AN - SCOPUS:84873494782
VL - 9
JO - PLoS Genetics
JF - PLoS Genetics
SN - 1553-7390
IS - 1
M1 - e1003217
ER -