TY - JOUR
T1 - Sexually transmitted infections and risk of hypertensive disorders of pregnancy
AU - DePaoli Taylor, Brandie
AU - Hill, Ashley V.
AU - Perez-Patron, Maria J.
AU - Haggerty, Catherine L.
AU - Schisterman, Enrique F.
AU - Naimi, Ashley I.
AU - Noah, Akaninyene
AU - Comeaux, Camillia R.
N1 - Funding Information:
We thank Peribank for allowing us access to the data used in this study and thank the women who participated. In Peribank, subject data were obtained following full and informed subject consent with the generous support from the Departments of Obstetrics and Gynecology and Pathology and Laboratory Medicine at Texas Children’s Hospital and Baylor College of Medicine on the PeriBank protocol (IRB H-26364, Dr. Kjersti Aagaard PI).
Funding Information:
This work was funded in part by NIH/NIAID R01AI143653 to B.D.T.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Hypertensive disorders of pregnancy (HDP) result in maternal morbidity and mortality but are rarely examined in perinatal studies of sexually transmitted infections. We examined associations between common sexually transmitted infections and HDP among 38,026 singleton pregnancies. Log-binomial regression calculated relative risk (RRs) and 95% confidence intervals (CIs) for associations with gestational hypertension, preeclampsia with severe features, mild preeclampsia, and superimposed preeclampsia. All models were adjusted for insurance type, maternal age, race/ethnicity, and education. Additional adjustments resulted in similar effect estimates. Chlamydia was associated with preeclampsia with severe features (RRadj. 1.4, 95% CI 1.1, 1.9). Effect estimates differed when we examined first prenatal visit diagnosis only (RRadj. 1.3, 95% CI 0.9, 1.9) and persistent or recurrent infection (RRadj. 2.0, 95% CI 1.1, 3.4). For chlamydia (RRadj. 2.0, 95% CI 1.3, 2.9) and gonorrhea (RRadj. 3.0, 95% CI 1.1, 12.2), women without a documented treatment were more likely to have preeclampsia with severe features. Among a diverse perinatal population, sexually transmitted infections may be associated with preeclampsia with severe features. With the striking increasing rates of sexually transmitted infections, there is a need to revisit the burden in pregnant women and determine if there is a link between infections and hypertensive disorders of pregnancy.
AB - Hypertensive disorders of pregnancy (HDP) result in maternal morbidity and mortality but are rarely examined in perinatal studies of sexually transmitted infections. We examined associations between common sexually transmitted infections and HDP among 38,026 singleton pregnancies. Log-binomial regression calculated relative risk (RRs) and 95% confidence intervals (CIs) for associations with gestational hypertension, preeclampsia with severe features, mild preeclampsia, and superimposed preeclampsia. All models were adjusted for insurance type, maternal age, race/ethnicity, and education. Additional adjustments resulted in similar effect estimates. Chlamydia was associated with preeclampsia with severe features (RRadj. 1.4, 95% CI 1.1, 1.9). Effect estimates differed when we examined first prenatal visit diagnosis only (RRadj. 1.3, 95% CI 0.9, 1.9) and persistent or recurrent infection (RRadj. 2.0, 95% CI 1.1, 3.4). For chlamydia (RRadj. 2.0, 95% CI 1.3, 2.9) and gonorrhea (RRadj. 3.0, 95% CI 1.1, 12.2), women without a documented treatment were more likely to have preeclampsia with severe features. Among a diverse perinatal population, sexually transmitted infections may be associated with preeclampsia with severe features. With the striking increasing rates of sexually transmitted infections, there is a need to revisit the burden in pregnant women and determine if there is a link between infections and hypertensive disorders of pregnancy.
UR - http://www.scopus.com/inward/record.url?scp=85136029021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85136029021&partnerID=8YFLogxK
U2 - 10.1038/s41598-022-17989-0
DO - 10.1038/s41598-022-17989-0
M3 - Article
C2 - 35974035
AN - SCOPUS:85136029021
SN - 2045-2322
VL - 12
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 13904
ER -