Shedding UV Light on Alternative Splicing

Matthew S. Marengo, Mariano Garcia-Blanco

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
JournalCell
Volume137
Issue number4
DOIs
StatePublished - May 15 2009
Externally publishedYes

Fingerprint

RNA Splicing
Alternative Splicing
Ultraviolet Rays
RNA Polymerase III
Messenger RNA
RNA Polymerase II
Transcription
DNA Damage
Elongation
Irradiation
DNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shedding UV Light on Alternative Splicing. / Marengo, Matthew S.; Garcia-Blanco, Mariano.

In: Cell, Vol. 137, No. 4, 15.05.2009, p. 600-602.

Research output: Contribution to journalArticle

Marengo, Matthew S. ; Garcia-Blanco, Mariano. / Shedding UV Light on Alternative Splicing. In: Cell. 2009 ; Vol. 137, No. 4. pp. 600-602.
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