Shedding UV Light on Alternative Splicing

Matthew S. Marengo; Mariano A. Garcia-Blanco

doi:10.1016/j.cell.2009.04.054

Shedding UV Light on Alternative Splicing

Matthew S. Marengo, Mariano A. Garcia-Blanco

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

Original language	English (US)
Pages (from-to)	600-602
Number of pages	3
Journal	Cell
Volume	137
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2009.04.054
State	Published - May 15 2009

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Shedding UV Light on Alternative Splicing",

abstract = "After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Mu{\~n}oz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.",

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AB - After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

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