Shedding UV Light on Alternative Splicing

Matthew S. Marengo; Mariano A. Garcia-Blanco

doi:10.1016/j.cell.2009.04.054

Shedding UV Light on Alternative Splicing

Matthew S. Marengo, Mariano A. Garcia-Blanco

Research output: Contribution to journal › Short survey

2 Scopus citations

Abstract

After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

Original language	English (US)
Pages (from-to)	600-602
Number of pages	3
Journal	Cell
Volume	137
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2009.04.054
State	Published - May 15 2009
Externally published	Yes

Fingerprint

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Marengo, M. S., & Garcia-Blanco, M. A. (2009). Shedding UV Light on Alternative Splicing. Cell, 137(4), 600-602. https://doi.org/10.1016/j.cell.2009.04.054

@article{bce47d7afb374f2ba11d32f6ad17c556,

title = "Shedding UV Light on Alternative Splicing",

abstract = "After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Mu{\~n}oz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.",

author = "Marengo, {Matthew S.} and Garcia-Blanco, {Mariano A.}",

year = "2009",

month = may,

day = "15",

doi = "10.1016/j.cell.2009.04.054",

language = "English (US)",

volume = "137",

pages = "600--602",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Shedding UV Light on Alternative Splicing

AU - Marengo, Matthew S.

AU - Garcia-Blanco, Mariano A.

PY - 2009/5/15

Y1 - 2009/5/15

N2 - After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

AB - After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.

UR - http://www.scopus.com/inward/record.url?scp=65549144751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549144751&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2009.04.054

DO - 10.1016/j.cell.2009.04.054

M3 - Short survey

C2 - 19450507

AN - SCOPUS:65549144751

VL - 137

SP - 600

EP - 602

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -

Access to Document

10.1016/j.cell.2009.04.054