Abstract
After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.
Original language | English (US) |
---|---|
Pages (from-to) | 600-602 |
Number of pages | 3 |
Journal | Cell |
Volume | 137 |
Issue number | 4 |
DOIs | |
State | Published - May 15 2009 |
Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Shedding UV Light on Alternative Splicing. / Marengo, Matthew S.; Garcia-Blanco, Mariano.
In: Cell, Vol. 137, No. 4, 15.05.2009, p. 600-602.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Shedding UV Light on Alternative Splicing
AU - Marengo, Matthew S.
AU - Garcia-Blanco, Mariano
PY - 2009/5/15
Y1 - 2009/5/15
N2 - After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.
AB - After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elongation.
UR - http://www.scopus.com/inward/record.url?scp=65549144751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65549144751&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2009.04.054
DO - 10.1016/j.cell.2009.04.054
M3 - Article
C2 - 19450507
AN - SCOPUS:65549144751
VL - 137
SP - 600
EP - 602
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -