Short-chain fatty acid enemas

A cost-effective alternative in the treatment of nonspecific proctosigmoiditis

Anthony J. Senagore, John M. MacKeigan, Michael Scheider, J. Stephen Ebrom

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The purpose of this study was to perform a randomized, prospective comparison of corticosteroid enemas (CS-100 mg of hydrocortisone/60 ccP.R. q.b.s.;n=12), mesalamine enemas (5-ASA-4 g/60 ccP.R. q.h.s.;n =19), and short-chain fatty acid enemas (SCFA-60 ccP.R. b.i.d.;n = 14) for the treatment of proctosigmoiditis. Patients presenting to the Ferguson Clinic with the diagnosis of idiopathic proctosigmoiditis were evaluated for age, sex, prior history of proctitis, duration of symptoms prior to presentation, endoscopic scoring, and mucosal biopsies. Clinical evaluation was performed at two-week intervals for six weeks, with repeat biopsies taken at six weeks. There was no significant difference with respect to age, male/female ratio, past history of proctosigmoiditis, length of colorectum involved at the time of initial presentation, symptom resolution, and endoscopic and histologic improvement among the three treatment groups. Recovery occurred in a similar proportion in each of the three groups: CS, 10/12; 5-ASA, 17/19; and SCFA, 12/14. The cost of six weeks of treatment was: CS, $71.82; 5-ASA, $347.28; and SCFA, $31.50. This study indicates that SCFA enemas are equally efficacious to CS or 5-ASA enemas for the treatment of proctosigmoiditis at a significant cost savings.

Original languageEnglish (US)
Pages (from-to)923-927
Number of pages5
JournalDiseases of the Colon and Rectum
Volume35
Issue number10
DOIs
StatePublished - Oct 1992
Externally publishedYes

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Proctocolitis
Volatile Fatty Acids
Enema
Costs and Cost Analysis
Proctitis
Biopsy
Therapeutics
Mesalamine
Cost Savings
Hydrocortisone
Adrenal Cortex Hormones

Keywords

  • Proctosigmoiditis
  • Short-chain fatty acids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Short-chain fatty acid enemas : A cost-effective alternative in the treatment of nonspecific proctosigmoiditis. / Senagore, Anthony J.; MacKeigan, John M.; Scheider, Michael; Ebrom, J. Stephen.

In: Diseases of the Colon and Rectum, Vol. 35, No. 10, 10.1992, p. 923-927.

Research output: Contribution to journalArticle

Senagore, Anthony J. ; MacKeigan, John M. ; Scheider, Michael ; Ebrom, J. Stephen. / Short-chain fatty acid enemas : A cost-effective alternative in the treatment of nonspecific proctosigmoiditis. In: Diseases of the Colon and Rectum. 1992 ; Vol. 35, No. 10. pp. 923-927.
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