Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma

Brent Siesky, Alon Harris, Rita Ehrlich, Louis Cantor, Mohammadali Mohajel Shoja, Deepam Rusia, David A. Hollander, Leslie Abrams, Julia M. Williams, Yochai Shoshani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: To examine the comparative short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with primary open angle glaucoma (OAG). Methods: In a prospective, randomized, double-blind, crossover study, intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), and retrobulbar hemodynamics were assessed in 15 patients with OAG (mean age 68.1 years, eight women) with well controlled IOP. IOP was measured by Goldman applanation tonometery and color Doppler imaging was utilized to assess the retrobulbar blood vessels before and 1 month after treatment with topical brimonidine/timolol and dorzolamide/timolol. Statistical analysis was performed by Friedman two-way analysis of variance by ranks and post-hoc Wilcoxon signed rank test for multiple comparisons with Holm's sequential Bonferroni procedure. P values <0.05 were considered statistically significant. Results: The Friedman test and subsequent post-hoc analysis indicated that IOP, BP, OPP, and retrobulbar blood flow velocities did not significantly differ between brimonidine/timolol and dorzolamide/timolol after 1-month treatment administration in patients with OAG and well controlled IOP. Conclusion: In this cohort of patients with OAG, short-term treatment with brimonidine/timolol and dorzolamide/timolol results in similar effects on OPP and retrobulbar blood flow velocities.

Original languageEnglish (US)
Pages (from-to)53-63
Number of pages11
JournalAdvances in Therapy
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

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dorzolamide
Timolol
Glaucoma
Perfusion
Blood Pressure
Intraocular Pressure
Open Angle Glaucoma
Blood Flow Velocity
Pressure
Brimonidine Tartrate
Nonparametric Statistics
Double-Blind Method
Cross-Over Studies
Blood Vessels

Keywords

  • glaucoma
  • gretrobulbar hemodynamics
  • intraocular pressure
  • ocular blood flow
  • ocular perfusion pressure
  • therapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)

Cite this

Siesky, B., Harris, A., Ehrlich, R., Cantor, L., Mohajel Shoja, M., Rusia, D., ... Shoshani, Y. (2012). Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma. Advances in Therapy, 29(1), 53-63. https://doi.org/10.1007/s12325-011-0092-3

Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma. / Siesky, Brent; Harris, Alon; Ehrlich, Rita; Cantor, Louis; Mohajel Shoja, Mohammadali; Rusia, Deepam; Hollander, David A.; Abrams, Leslie; Williams, Julia M.; Shoshani, Yochai.

In: Advances in Therapy, Vol. 29, No. 1, 01.01.2012, p. 53-63.

Research output: Contribution to journalArticle

Siesky, B, Harris, A, Ehrlich, R, Cantor, L, Mohajel Shoja, M, Rusia, D, Hollander, DA, Abrams, L, Williams, JM & Shoshani, Y 2012, 'Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma', Advances in Therapy, vol. 29, no. 1, pp. 53-63. https://doi.org/10.1007/s12325-011-0092-3
Siesky, Brent ; Harris, Alon ; Ehrlich, Rita ; Cantor, Louis ; Mohajel Shoja, Mohammadali ; Rusia, Deepam ; Hollander, David A. ; Abrams, Leslie ; Williams, Julia M. ; Shoshani, Yochai. / Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma. In: Advances in Therapy. 2012 ; Vol. 29, No. 1. pp. 53-63.
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abstract = "Introduction: To examine the comparative short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with primary open angle glaucoma (OAG). Methods: In a prospective, randomized, double-blind, crossover study, intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), and retrobulbar hemodynamics were assessed in 15 patients with OAG (mean age 68.1 years, eight women) with well controlled IOP. IOP was measured by Goldman applanation tonometery and color Doppler imaging was utilized to assess the retrobulbar blood vessels before and 1 month after treatment with topical brimonidine/timolol and dorzolamide/timolol. Statistical analysis was performed by Friedman two-way analysis of variance by ranks and post-hoc Wilcoxon signed rank test for multiple comparisons with Holm's sequential Bonferroni procedure. P values <0.05 were considered statistically significant. Results: The Friedman test and subsequent post-hoc analysis indicated that IOP, BP, OPP, and retrobulbar blood flow velocities did not significantly differ between brimonidine/timolol and dorzolamide/timolol after 1-month treatment administration in patients with OAG and well controlled IOP. Conclusion: In this cohort of patients with OAG, short-term treatment with brimonidine/timolol and dorzolamide/timolol results in similar effects on OPP and retrobulbar blood flow velocities.",
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AU - Mohajel Shoja, Mohammadali

AU - Rusia, Deepam

AU - Hollander, David A.

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N2 - Introduction: To examine the comparative short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with primary open angle glaucoma (OAG). Methods: In a prospective, randomized, double-blind, crossover study, intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), and retrobulbar hemodynamics were assessed in 15 patients with OAG (mean age 68.1 years, eight women) with well controlled IOP. IOP was measured by Goldman applanation tonometery and color Doppler imaging was utilized to assess the retrobulbar blood vessels before and 1 month after treatment with topical brimonidine/timolol and dorzolamide/timolol. Statistical analysis was performed by Friedman two-way analysis of variance by ranks and post-hoc Wilcoxon signed rank test for multiple comparisons with Holm's sequential Bonferroni procedure. P values <0.05 were considered statistically significant. Results: The Friedman test and subsequent post-hoc analysis indicated that IOP, BP, OPP, and retrobulbar blood flow velocities did not significantly differ between brimonidine/timolol and dorzolamide/timolol after 1-month treatment administration in patients with OAG and well controlled IOP. Conclusion: In this cohort of patients with OAG, short-term treatment with brimonidine/timolol and dorzolamide/timolol results in similar effects on OPP and retrobulbar blood flow velocities.

AB - Introduction: To examine the comparative short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with primary open angle glaucoma (OAG). Methods: In a prospective, randomized, double-blind, crossover study, intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), and retrobulbar hemodynamics were assessed in 15 patients with OAG (mean age 68.1 years, eight women) with well controlled IOP. IOP was measured by Goldman applanation tonometery and color Doppler imaging was utilized to assess the retrobulbar blood vessels before and 1 month after treatment with topical brimonidine/timolol and dorzolamide/timolol. Statistical analysis was performed by Friedman two-way analysis of variance by ranks and post-hoc Wilcoxon signed rank test for multiple comparisons with Holm's sequential Bonferroni procedure. P values <0.05 were considered statistically significant. Results: The Friedman test and subsequent post-hoc analysis indicated that IOP, BP, OPP, and retrobulbar blood flow velocities did not significantly differ between brimonidine/timolol and dorzolamide/timolol after 1-month treatment administration in patients with OAG and well controlled IOP. Conclusion: In this cohort of patients with OAG, short-term treatment with brimonidine/timolol and dorzolamide/timolol results in similar effects on OPP and retrobulbar blood flow velocities.

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