Short Term Performance Evaluation of a Perfluorocopolymer Coated Gas Exchanger for Arteriovenous CO2 Removal

Dongfang Wang, Scott K. Alpard, Clare Savage, Hussein N. Yamani, Donald J. Deyo, Stuart Nemser, Joseph B. Zwischenberger

    1 Scopus citations

    Abstract

    A new perfluorocopolymer coating for micropore hollow fiber gas exchangers was developed to improve gas exchange, reduce plasma leakage, and reduce blood-surface interactions. The present authors evaluated gas exchanger performance using this new coating in a prospective, randomized, controlled, unblinded, large animal model of CO2 retention. Adult sheep (30-40 kg), under general anesthesia, underwent cannulation of the carotid artery (12 F) and jugular vein (14 F). The perfluorocopolymer coated (n = 5) and uncoated (n = 5) gas exchangers were attached to an arteriovenous CO2 removal (AVCO2R) circuit. Blood gases, CO2 removal, and hemodynamics were monitored throughout the 6 hour study. Average CO2 removal was 107.6 ± 15.6 ml/min (coated) vs. 93.0 ± 13.9 ml/min (uncoated; p < 0.01). PaCO2 and CO2 removal for both coated and uncoated did not deteriorate significantly over the study. Average AVCO2R blood flow was 1,130 ± 25 ml/min (coated) versus 1,101 ± 79 ml/min (uncoated; p = not significant). Likewise, cardiac output and AVCO2R blood flow did not change over the duration of the study. No significant differences in the pressure gradient or resistance between devices (coated, 6.89 ± 1.14 mm Hg/L/min; uncoated, 6.42 ± 0.23 mm Hg/L/min) was noted. The authors concluded that the new perfluorocopolymer coated gas exchanger improved CO2 removal without compromising hemodynamics in an acute performance evaluation.

    Original languageEnglish (US)
    Pages (from-to)673-677
    Number of pages5
    JournalASAIO Journal
    Volume49
    Issue number6
    DOIs
    StatePublished - Nov 2003

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    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Short Term Performance Evaluation of a Perfluorocopolymer Coated Gas Exchanger for Arteriovenous CO2 Removal. / Wang, Dongfang; Alpard, Scott K.; Savage, Clare; Yamani, Hussein N.; Deyo, Donald J.; Nemser, Stuart; Zwischenberger, Joseph B.

    In: ASAIO Journal, Vol. 49, No. 6, 11.2003, p. 673-677.

    Research output: Contribution to journalArticle