Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

Gerald Ehrenstein; Li Yen Mae Huang

doi:10.1126/science.7313696

Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

Gerald Ehrenstein
, Li Yen Mae Huang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

If two drugs cause the same molecular effect by binding to separate noncompetitive binding sites, therapy with a mixture of the two drugs can provide a given desired effect with a lower level of side effects than therapy with either drug alone.

Original language	English (US)
Pages (from-to)	1365-1366
Number of pages	2
Journal	Science
Volume	214
Issue number	4527
DOIs	https://doi.org/10.1126/science.7313696
State	Published - 1981
Externally published	Yes

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title = "Side-effect reduction by use of drugs that bind to separate but equivalent binding sites",

abstract = "If two drugs cause the same molecular effect by binding to separate noncompetitive binding sites, therapy with a mixture of the two drugs can provide a given desired effect with a lower level of side effects than therapy with either drug alone.",

author = "Gerald Ehrenstein and Huang, \{Li Yen Mae\}",

year = "1981",

doi = "10.1126/science.7313696",

language = "English (US)",

volume = "214",

pages = "1365--1366",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

AU - Ehrenstein, Gerald

AU - Huang, Li Yen Mae

PY - 1981

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AB - If two drugs cause the same molecular effect by binding to separate noncompetitive binding sites, therapy with a mixture of the two drugs can provide a given desired effect with a lower level of side effects than therapy with either drug alone.

UR - https://www.scopus.com/pages/publications/0019799798

UR - https://www.scopus.com/pages/publications/0019799798#tab=citedBy

U2 - 10.1126/science.7313696

DO - 10.1126/science.7313696

M3 - Article

C2 - 7313696

AN - SCOPUS:0019799798

SN - 0036-8075

VL - 214

SP - 1365

EP - 1366

JO - Science

JF - Science

IS - 4527

ER -

Side-effect reduction by use of drugs that bind to separate but equivalent binding sites

Abstract

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