TY - JOUR
T1 - Side-to-side differences in transcranial Doppler parameters in normotensive and preeclamptic pregnant women
AU - Riskin-Mashiah, Shlomit
AU - Belfort, Michael A.
AU - Saade, George R.
AU - Herd, Alan J.
N1 - Funding Information:
Supported by a grant from the National Institute of Health, No. MO1-00188, General Clinical Research Center (M. A. B., S. R. M., A. J. H.).
PY - 2004/1
Y1 - 2004/1
N2 - Objective: This study was undertaken to investigate whether women with preeclampsia demonstrate larger side-to-side velocity differences in the middle cerebral artery (MCA) compared with normotensive pregnant women. Study design: Forty-one preeclamptic women and 50 normotensive pregnant women were studied during the third trimester. Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in both MCAs. An asymmetry index was calculated as 100 × Rt - Lt|/(Rt + Lt)/2, for each of the following parameters: mean velocity (Vm), pulsatility index (PI), and cerebral perfusion pressure (CPP). Student t test, Pearson correlation, and regression analysis were used. Significance was taken as P < .05. Results: Both normotensive and preeclamptic pregnant women showed good correlation between Rt and Lt MCA Vm (R > 0.8, P <. 0001), PI (R > 0.6, P .0001), and CPP (R > 0.8, P < .0001). There were no differences in the asymmetry index for Vm, PI, or CPP beween the two groups. Conclusion: Preeclampsia does not appear to induce greater side-to-side velocity differences in the MCA distribution.
AB - Objective: This study was undertaken to investigate whether women with preeclampsia demonstrate larger side-to-side velocity differences in the middle cerebral artery (MCA) compared with normotensive pregnant women. Study design: Forty-one preeclamptic women and 50 normotensive pregnant women were studied during the third trimester. Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in both MCAs. An asymmetry index was calculated as 100 × Rt - Lt|/(Rt + Lt)/2, for each of the following parameters: mean velocity (Vm), pulsatility index (PI), and cerebral perfusion pressure (CPP). Student t test, Pearson correlation, and regression analysis were used. Significance was taken as P < .05. Results: Both normotensive and preeclamptic pregnant women showed good correlation between Rt and Lt MCA Vm (R > 0.8, P <. 0001), PI (R > 0.6, P .0001), and CPP (R > 0.8, P < .0001). There were no differences in the asymmetry index for Vm, PI, or CPP beween the two groups. Conclusion: Preeclampsia does not appear to induce greater side-to-side velocity differences in the MCA distribution.
KW - Middle cerebral artery
KW - Preeclampsia
KW - Side-to-side differences
KW - Transcranial Doppler ultrasound
UR - http://www.scopus.com/inward/record.url?scp=0742304269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0742304269&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2003.07.005
DO - 10.1016/j.ajog.2003.07.005
M3 - Article
C2 - 14749659
AN - SCOPUS:0742304269
SN - 0002-9378
VL - 190
SP - 194
EP - 198
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 1
ER -