Side-to-side differences in transcranial Doppler parameters in normotensive and preeclamptic pregnant women

Shlomit Riskin-Mashiah, Michael A. Belfort, George Saade, Alan J. Herd

Research output: Contribution to journalArticle

5 Scopus citations


Objective: This study was undertaken to investigate whether women with preeclampsia demonstrate larger side-to-side velocity differences in the middle cerebral artery (MCA) compared with normotensive pregnant women. Study design: Forty-one preeclamptic women and 50 normotensive pregnant women were studied during the third trimester. Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in both MCAs. An asymmetry index was calculated as 100 × Rt - Lt|/(Rt + Lt)/2, for each of the following parameters: mean velocity (Vm), pulsatility index (PI), and cerebral perfusion pressure (CPP). Student t test, Pearson correlation, and regression analysis were used. Significance was taken as P < .05. Results: Both normotensive and preeclamptic pregnant women showed good correlation between Rt and Lt MCA Vm (R > 0.8, P <. 0001), PI (R > 0.6, P .0001), and CPP (R > 0.8, P < .0001). There were no differences in the asymmetry index for Vm, PI, or CPP beween the two groups. Conclusion: Preeclampsia does not appear to induce greater side-to-side velocity differences in the MCA distribution.

Original languageEnglish (US)
Pages (from-to)194-198
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
StatePublished - Jan 2004
Externally publishedYes



  • Middle cerebral artery
  • Preeclampsia
  • Side-to-side differences
  • Transcranial Doppler ultrasound

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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