TY - JOUR
T1 - Signal transduction in neuronal death
AU - Tong, Liqi
AU - Toliver-Kinsky, Tracy
AU - Taglialatela, Giulio
AU - Werrbach-Perez, Karin
AU - Wood, Thomas
AU - Perez-Polo, Jose R
PY - 1998/8
Y1 - 1998/8
N2 - Apoptosis in the nervous system is a necessary event during the development of the nervous system and is also present after genotoxic events, be they chronic as in aging or more acute after trauma and ischemia. Apoptotic events reflect an interplay between intrinsic signaling events that rely on cytokines, neurotransmitters, and growth factors and responses to extrinsic events that increase levels of radical oxygen species. Both intrinsically and extrinsically driven signal-transduction pathways act via transcription factors that regulate the coordinated timely expression of stress-response genes as part of a decision-making process that can commit cells to apoptosis or survival. Here we discuss the role of two transcription factors that participate in apoptosis n the nervous system: the activator protein AP-1 and nuclear factor κB.
AB - Apoptosis in the nervous system is a necessary event during the development of the nervous system and is also present after genotoxic events, be they chronic as in aging or more acute after trauma and ischemia. Apoptotic events reflect an interplay between intrinsic signaling events that rely on cytokines, neurotransmitters, and growth factors and responses to extrinsic events that increase levels of radical oxygen species. Both intrinsically and extrinsically driven signal-transduction pathways act via transcription factors that regulate the coordinated timely expression of stress-response genes as part of a decision-making process that can commit cells to apoptosis or survival. Here we discuss the role of two transcription factors that participate in apoptosis n the nervous system: the activator protein AP-1 and nuclear factor κB.
KW - Activator protein- 1
KW - Apoptosis
KW - Nuclear factor κB
KW - Signal transduction
KW - Transcription factors
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U2 - 10.1046/j.1471-4159.1998.71020447.x
DO - 10.1046/j.1471-4159.1998.71020447.x
M3 - Short survey
C2 - 9681434
AN - SCOPUS:0031783646
SN - 0022-3042
VL - 71
SP - 447
EP - 459
JO - Journal of neurochemistry
JF - Journal of neurochemistry
IS - 2
ER -