Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases

Xueqing Ba, Nisha Jain Garg

Research output: Contribution to journalReview article

125 Scopus citations

Abstract

Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to the receptor protein, is a unique posttranslational modification. Poly(ADP-ribose) polymerase-1 (PARP-1) is a well-characterized member of the PARP family. In this review, we provide a general update on molecular structure and structure-based activity of this enzyme. However, we mainly focus on the roles of PARP-1 in inflammatory diseases. Specifically, we discuss the signaling pathway context that PARP-1 is involved in to regulate the pathogenesis of inflammation. PARP-1 facilitates diverse inflammatory responses by promoting inflammation-relevant gene expression, such as cytokines, oxidation-reduction - related enzymes, and adhesion molecules. Excessive activation of PARP-1 induces mitochondria- associated cell death in injured tissues and constitutes another mechanism for exacerbating inflammation.

Original languageEnglish (US)
Pages (from-to)946-955
Number of pages10
JournalAmerican Journal of Pathology
Volume178
Issue number3
DOIs
StatePublished - Mar 2011

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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