Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases

Xueqing Ba; Nisha Jain Garg

doi:10.1016/j.ajpath.2010.12.004

Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases

Xueqing Ba
, Nisha Jain Garg

Microbiology And Immunology

Research output: Contribution to journal › Review article › peer-review

194 Scopus citations

Abstract

Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to the receptor protein, is a unique posttranslational modification. Poly(ADP-ribose) polymerase-1 (PARP-1) is a well-characterized member of the PARP family. In this review, we provide a general update on molecular structure and structure-based activity of this enzyme. However, we mainly focus on the roles of PARP-1 in inflammatory diseases. Specifically, we discuss the signaling pathway context that PARP-1 is involved in to regulate the pathogenesis of inflammation. PARP-1 facilitates diverse inflammatory responses by promoting inflammation-relevant gene expression, such as cytokines, oxidation-reduction - related enzymes, and adhesion molecules. Excessive activation of PARP-1 induces mitochondria- associated cell death in injured tissues and constitutes another mechanism for exacerbating inflammation.

Original language	English (US)
Pages (from-to)	946-955
Number of pages	10
Journal	American Journal of Pathology
Volume	178
Issue number	3
DOIs	https://doi.org/10.1016/j.ajpath.2010.12.004
State	Published - Mar 2011

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.ajpath.2010.12.004

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title = "Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases",

abstract = "Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to the receptor protein, is a unique posttranslational modification. Poly(ADP-ribose) polymerase-1 (PARP-1) is a well-characterized member of the PARP family. In this review, we provide a general update on molecular structure and structure-based activity of this enzyme. However, we mainly focus on the roles of PARP-1 in inflammatory diseases. Specifically, we discuss the signaling pathway context that PARP-1 is involved in to regulate the pathogenesis of inflammation. PARP-1 facilitates diverse inflammatory responses by promoting inflammation-relevant gene expression, such as cytokines, oxidation-reduction - related enzymes, and adhesion molecules. Excessive activation of PARP-1 induces mitochondria- associated cell death in injured tissues and constitutes another mechanism for exacerbating inflammation.",

author = "Xueqing Ba and Garg, \{Nisha Jain\}",

note = "Funding Information: Supported by grants from the NIH ( AI053098 and HL094802 to N.J.G.) for work performed in the laboratory related to mitochondrial dysfunction and chronic inflammation. ",

year = "2011",

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doi = "10.1016/j.ajpath.2010.12.004",

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T1 - Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases

AU - Ba, Xueqing

AU - Garg, Nisha Jain

N1 - Funding Information: Supported by grants from the NIH ( AI053098 and HL094802 to N.J.G.) for work performed in the laboratory related to mitochondrial dysfunction and chronic inflammation.

PY - 2011/3

Y1 - 2011/3

N2 - Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to the receptor protein, is a unique posttranslational modification. Poly(ADP-ribose) polymerase-1 (PARP-1) is a well-characterized member of the PARP family. In this review, we provide a general update on molecular structure and structure-based activity of this enzyme. However, we mainly focus on the roles of PARP-1 in inflammatory diseases. Specifically, we discuss the signaling pathway context that PARP-1 is involved in to regulate the pathogenesis of inflammation. PARP-1 facilitates diverse inflammatory responses by promoting inflammation-relevant gene expression, such as cytokines, oxidation-reduction - related enzymes, and adhesion molecules. Excessive activation of PARP-1 induces mitochondria- associated cell death in injured tissues and constitutes another mechanism for exacerbating inflammation.

AB - Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to the receptor protein, is a unique posttranslational modification. Poly(ADP-ribose) polymerase-1 (PARP-1) is a well-characterized member of the PARP family. In this review, we provide a general update on molecular structure and structure-based activity of this enzyme. However, we mainly focus on the roles of PARP-1 in inflammatory diseases. Specifically, we discuss the signaling pathway context that PARP-1 is involved in to regulate the pathogenesis of inflammation. PARP-1 facilitates diverse inflammatory responses by promoting inflammation-relevant gene expression, such as cytokines, oxidation-reduction - related enzymes, and adhesion molecules. Excessive activation of PARP-1 induces mitochondria- associated cell death in injured tissues and constitutes another mechanism for exacerbating inflammation.

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DO - 10.1016/j.ajpath.2010.12.004

M3 - Review article

C2 - 21356345

AN - SCOPUS:79952768723

SN - 0002-9440

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JF - American Journal of Pathology

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Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases

Abstract

ASJC Scopus subject areas

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