Signet-ring cell variant of invasive lobular carcinoma of the breast

A clinicopathologic study of 11 cases

M. Eltorky, J. C. Hall, P. T. Osborne, F. El Zeky

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In signet-ring cell carcinoma of the breast, which was recognized in 1976 as a distinct clinicopathologic variant of lobular carcinoma, more than 20% of the malignant cells appear as signet rings formed by mucin-positive intracytoplasmic vacuoles. Several recent studies have demonstrated that the neoplasm behaves aggressively and is associated with a poor prognosis. However, the literature lacks information concerning steroid hormone receptor assays and DNA ploidy profiles, especially regarding how these tests affect a patient's prognosis. During a 5-year period (1985 to 1990), 11 (8.7%) of 126 cases of invasive lobular carcinoma met the criteria for signet-ring cell carcinoma. Ten of 11 cases were positive for estrogen and progesterone receptors; six cases showed type I and five showed type III DNA histograms. The high incidence of positive hormone receptors is significant: patients with receptor positive tumors, even those with type III DNA histograms, who were treated with tamoxifen citrate therapy after surgery had a significant increase in disease-free survival (30 months). Both the pathologist and the clinician should be aware of the prognostic influence of hormone receptor studies in the management of signet-ring cell carcinoma of the breast.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume118
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Signet Ring Cell Carcinoma
Lobular Carcinoma
Breast
Hormones
DNA
Steroid Receptors
Ploidies
Mucins
Progesterone Receptors
Tamoxifen
Vacuoles
Estrogen Receptors
Disease-Free Survival
Neoplasms
Incidence
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Signet-ring cell variant of invasive lobular carcinoma of the breast : A clinicopathologic study of 11 cases. / Eltorky, M.; Hall, J. C.; Osborne, P. T.; El Zeky, F.

In: Archives of Pathology and Laboratory Medicine, Vol. 118, No. 3, 1994, p. 245-248.

Research output: Contribution to journalArticle

Eltorky, M. ; Hall, J. C. ; Osborne, P. T. ; El Zeky, F. / Signet-ring cell variant of invasive lobular carcinoma of the breast : A clinicopathologic study of 11 cases. In: Archives of Pathology and Laboratory Medicine. 1994 ; Vol. 118, No. 3. pp. 245-248.
@article{0b572f36648b4f54b76e1f108f46e783,
title = "Signet-ring cell variant of invasive lobular carcinoma of the breast: A clinicopathologic study of 11 cases",
abstract = "In signet-ring cell carcinoma of the breast, which was recognized in 1976 as a distinct clinicopathologic variant of lobular carcinoma, more than 20{\%} of the malignant cells appear as signet rings formed by mucin-positive intracytoplasmic vacuoles. Several recent studies have demonstrated that the neoplasm behaves aggressively and is associated with a poor prognosis. However, the literature lacks information concerning steroid hormone receptor assays and DNA ploidy profiles, especially regarding how these tests affect a patient's prognosis. During a 5-year period (1985 to 1990), 11 (8.7{\%}) of 126 cases of invasive lobular carcinoma met the criteria for signet-ring cell carcinoma. Ten of 11 cases were positive for estrogen and progesterone receptors; six cases showed type I and five showed type III DNA histograms. The high incidence of positive hormone receptors is significant: patients with receptor positive tumors, even those with type III DNA histograms, who were treated with tamoxifen citrate therapy after surgery had a significant increase in disease-free survival (30 months). Both the pathologist and the clinician should be aware of the prognostic influence of hormone receptor studies in the management of signet-ring cell carcinoma of the breast.",
author = "M. Eltorky and Hall, {J. C.} and Osborne, {P. T.} and {El Zeky}, F.",
year = "1994",
language = "English (US)",
volume = "118",
pages = "245--248",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "3",

}

TY - JOUR

T1 - Signet-ring cell variant of invasive lobular carcinoma of the breast

T2 - A clinicopathologic study of 11 cases

AU - Eltorky, M.

AU - Hall, J. C.

AU - Osborne, P. T.

AU - El Zeky, F.

PY - 1994

Y1 - 1994

N2 - In signet-ring cell carcinoma of the breast, which was recognized in 1976 as a distinct clinicopathologic variant of lobular carcinoma, more than 20% of the malignant cells appear as signet rings formed by mucin-positive intracytoplasmic vacuoles. Several recent studies have demonstrated that the neoplasm behaves aggressively and is associated with a poor prognosis. However, the literature lacks information concerning steroid hormone receptor assays and DNA ploidy profiles, especially regarding how these tests affect a patient's prognosis. During a 5-year period (1985 to 1990), 11 (8.7%) of 126 cases of invasive lobular carcinoma met the criteria for signet-ring cell carcinoma. Ten of 11 cases were positive for estrogen and progesterone receptors; six cases showed type I and five showed type III DNA histograms. The high incidence of positive hormone receptors is significant: patients with receptor positive tumors, even those with type III DNA histograms, who were treated with tamoxifen citrate therapy after surgery had a significant increase in disease-free survival (30 months). Both the pathologist and the clinician should be aware of the prognostic influence of hormone receptor studies in the management of signet-ring cell carcinoma of the breast.

AB - In signet-ring cell carcinoma of the breast, which was recognized in 1976 as a distinct clinicopathologic variant of lobular carcinoma, more than 20% of the malignant cells appear as signet rings formed by mucin-positive intracytoplasmic vacuoles. Several recent studies have demonstrated that the neoplasm behaves aggressively and is associated with a poor prognosis. However, the literature lacks information concerning steroid hormone receptor assays and DNA ploidy profiles, especially regarding how these tests affect a patient's prognosis. During a 5-year period (1985 to 1990), 11 (8.7%) of 126 cases of invasive lobular carcinoma met the criteria for signet-ring cell carcinoma. Ten of 11 cases were positive for estrogen and progesterone receptors; six cases showed type I and five showed type III DNA histograms. The high incidence of positive hormone receptors is significant: patients with receptor positive tumors, even those with type III DNA histograms, who were treated with tamoxifen citrate therapy after surgery had a significant increase in disease-free survival (30 months). Both the pathologist and the clinician should be aware of the prognostic influence of hormone receptor studies in the management of signet-ring cell carcinoma of the breast.

UR - http://www.scopus.com/inward/record.url?scp=0028209097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028209097&partnerID=8YFLogxK

M3 - Article

VL - 118

SP - 245

EP - 248

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 3

ER -