Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device

Weike Tao, Donald J. Deyo, Scott K. Alpard, Roger A. Vertrees, Vivi Hoang, Joseph B. Zwischenberger

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The heparin removal device (HRD), using plasma separation and poly-L- lysine (PLL) affinity adsorption, has been shown to be an effective alternative to protamine after cardiopulmonary bypass (CPB). Previous designs of the HRD used standard Luer-Lok (φ = 2.3 mm) port connections between the extracorporeal tubing and the plasma separation chambers, which resulted in excessively high circuit pressures (> 750 mm Hg) at an HRD flow of 1,400 ml/min. To reduce circuit pressures, we enlarged the connection ports to φ = 4.2 mm, keeping other circuit components and sorbent amounts unchanged. The modified circuit HRD was divided into the SMALL PORT group (φ = 2.3 mm, A = 4.15 mm2) and the LARGE PORT group (φ = 4.2 mm, A = 13.85 mm2) in adult swine (70 ± 5 kg) given 300 U/kg heparin. A dual lumen cannula was inserted into the right atrium and connected to the HRD. Inlet pressure ranged from 749 ± 42 to 795 ± 57 mm Hg in the SMALL PORT group during the HRD run at 1,400 ml/min, whereas it ranged from 345 ± 5 to 372 ± 34 mm Hg in the LARGE PORT group (p < 0.01 between groups). Likewise, the chamber pressure ranged from 447 ± 21 to 452 ± 27 mm Hg in the SMALL PORT group and from 190 ± 14 to 204 ± 19 mm Hg in the LARGE PORT group (p < 0.01 between groups). There were no significant differences in ACT between groups. We conclude that enlarged chamber ports significantly lower circuit pressures for the HRD without changing heparin removal capability.

    Original languageEnglish (US)
    Pages (from-to)50-52
    Number of pages3
    JournalASAIO Journal
    Volume45
    Issue number1
    StatePublished - Jan 1999

    Fingerprint

    Device Removal
    Heparin
    Plasmas
    Pressure
    Networks (circuits)
    Plasma devices
    Protamines
    Tubing
    Sorbents
    Heart Atria
    Cardiopulmonary Bypass
    Adsorption
    Lysine
    Swine

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Tao, W., Deyo, D. J., Alpard, S. K., Vertrees, R. A., Hoang, V., & Zwischenberger, J. B. (1999). Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device. ASAIO Journal, 45(1), 50-52.

    Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device. / Tao, Weike; Deyo, Donald J.; Alpard, Scott K.; Vertrees, Roger A.; Hoang, Vivi; Zwischenberger, Joseph B.

    In: ASAIO Journal, Vol. 45, No. 1, 01.1999, p. 50-52.

    Research output: Contribution to journalArticle

    Tao, W, Deyo, DJ, Alpard, SK, Vertrees, RA, Hoang, V & Zwischenberger, JB 1999, 'Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device', ASAIO Journal, vol. 45, no. 1, pp. 50-52.
    Tao W, Deyo DJ, Alpard SK, Vertrees RA, Hoang V, Zwischenberger JB. Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device. ASAIO Journal. 1999 Jan;45(1):50-52.
    Tao, Weike ; Deyo, Donald J. ; Alpard, Scott K. ; Vertrees, Roger A. ; Hoang, Vivi ; Zwischenberger, Joseph B. / Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device. In: ASAIO Journal. 1999 ; Vol. 45, No. 1. pp. 50-52.
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