Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure

Weike Tao, Robert L. Brunston, Akhil Bidani, Philip Pirtle, James Dy, Victor J. Cardenas, Daniel L. Traber, Joseph B. Zwischenberger

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objectives: To quantify CO2 removal using an extracorporeal low- resistance membrane gas exchanger placed in an arteriovenous shunt and evaluate its effects on the reduction of ventilatory volumes and airway pressures during severe respiratory failure induced by smoke inhalation injury. Design: Prospective study. Setting: Research laboratory. Subjects: Adult female sheep (n = 5). Interventions: Animals were instrumented with femoral and pulmonary arterial catheters and underwent an LD50 cotton smoke inhalation injury via a tracheostomy under halothane anesthesia. Twenty-four hours after smoke inhalation injury, the animals were reanesthetized and systemically heparinized for cannulation of the left carotid artery end common jugular vein to construct a simple arteriovenous shunt. A membrane gas exchanger was interposed within the arteriovenous shunt, and blood flow produced by the arteriovenous pressure gradient was unrestricted at the time of complete recovery from anesthesia. CO2 removal by the gas exchanger was measured as the product of the sweep gas flow (FIO2 of 1.0 at 2.5 to 3.0 L/min) and the exhaust CO2 content measured with an inline capnometer. CO2 removed by the animal's lungs was determined by the expired gas CO2 content in a Douglas bag. We made stepwise, 20% reductions in ventilator support hourly. We first reduced the tidal volume to achieve a peak inspiratory pressure of <30 cm H2O, and then we reduced the respiratory rate while maintaining normocapnia. Pao2 was maintained by adjusting the FIO2 and the level of positive end-expiratory pressure. Measurements and Main Results: Mean blood flow through the arteriovenous shunt ranged from 1154 ± 82 mL/min (25% cardiac output) to 1277 ± 38 mL/min (29% cardiac output) over the 6-hr study period. The pressure gradient across the gas exchanger was always <10 mm Hg. Maximum arteriovenous CO2 removal was 102.0 ± 9.5 mL/min (96% of total CO2 production), allowing minute ventilation to be reduced from 10.3 ± 1.4 L/min (baseline) to 0.5 ± 0.0 L/min st 6 hrs of arteriovenous CO2 removal while maintaining normocapnia. Similarly, peak inspiratory pressure decreased from 40.8 ± 2.1 to 19.7 ± 7.5 cm H20. Pao2 was maintained at >100 torr (>13.3 kPa) at maximally reduced ventilator support. Mean arterial pressure and cardiac output did not change significantly as a result of arteriovenous shunting. Conclusions: Extracorporeal CO2 removal using a low- resistance gas exchanger in a simple arteriovenous shunt allows significant reduction in minute ventilation and peak inspiratory pressure without hypercapnia or the complex circuitry and monitoring required for conventional extracorporeal membrane oxygenation. Arteriovenous CO2 removal can be applied as an easy and cost-effective treatment to minimize ventilator- induced barotrauma and volutrauma during severe respiratory failure.

Original languageEnglish (US)
Pages (from-to)689-695
Number of pages7
JournalCritical Care Medicine
Volume25
Issue number4
StatePublished - 1997

Fingerprint

Respiratory Insufficiency
Ventilation
Smoke Inhalation Injury
Gases
Pressure
Mechanical Ventilators
Anesthesia
Barotrauma
Lung
Extracorporeal Membrane Oxygenation
Membranes
Hypercapnia
Tracheostomy
Common Carotid Artery
Lethal Dose 50
Tidal Volume
Jugular Veins
Halothane
Thigh
Catheterization

Keywords

  • acute respiratory failure
  • adult respiratory distress syndrome
  • barotrauma
  • extracorporeal CO removal
  • extracorporeal membrane oxygenation
  • sheep
  • ventilator
  • volutrauma

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Tao, W., Brunston, R. L., Bidani, A., Pirtle, P., Dy, J., Cardenas, V. J., ... Zwischenberger, J. B. (1997). Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure. Critical Care Medicine, 25(4), 689-695.

Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure. / Tao, Weike; Brunston, Robert L.; Bidani, Akhil; Pirtle, Philip; Dy, James; Cardenas, Victor J.; Traber, Daniel L.; Zwischenberger, Joseph B.

In: Critical Care Medicine, Vol. 25, No. 4, 1997, p. 689-695.

Research output: Contribution to journalArticle

Tao, W, Brunston, RL, Bidani, A, Pirtle, P, Dy, J, Cardenas, VJ, Traber, DL & Zwischenberger, JB 1997, 'Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure', Critical Care Medicine, vol. 25, no. 4, pp. 689-695.
Tao, Weike ; Brunston, Robert L. ; Bidani, Akhil ; Pirtle, Philip ; Dy, James ; Cardenas, Victor J. ; Traber, Daniel L. ; Zwischenberger, Joseph B. / Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure. In: Critical Care Medicine. 1997 ; Vol. 25, No. 4. pp. 689-695.
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abstract = "Objectives: To quantify CO2 removal using an extracorporeal low- resistance membrane gas exchanger placed in an arteriovenous shunt and evaluate its effects on the reduction of ventilatory volumes and airway pressures during severe respiratory failure induced by smoke inhalation injury. Design: Prospective study. Setting: Research laboratory. Subjects: Adult female sheep (n = 5). Interventions: Animals were instrumented with femoral and pulmonary arterial catheters and underwent an LD50 cotton smoke inhalation injury via a tracheostomy under halothane anesthesia. Twenty-four hours after smoke inhalation injury, the animals were reanesthetized and systemically heparinized for cannulation of the left carotid artery end common jugular vein to construct a simple arteriovenous shunt. A membrane gas exchanger was interposed within the arteriovenous shunt, and blood flow produced by the arteriovenous pressure gradient was unrestricted at the time of complete recovery from anesthesia. CO2 removal by the gas exchanger was measured as the product of the sweep gas flow (FIO2 of 1.0 at 2.5 to 3.0 L/min) and the exhaust CO2 content measured with an inline capnometer. CO2 removed by the animal's lungs was determined by the expired gas CO2 content in a Douglas bag. We made stepwise, 20{\%} reductions in ventilator support hourly. We first reduced the tidal volume to achieve a peak inspiratory pressure of <30 cm H2O, and then we reduced the respiratory rate while maintaining normocapnia. Pao2 was maintained by adjusting the FIO2 and the level of positive end-expiratory pressure. Measurements and Main Results: Mean blood flow through the arteriovenous shunt ranged from 1154 ± 82 mL/min (25{\%} cardiac output) to 1277 ± 38 mL/min (29{\%} cardiac output) over the 6-hr study period. The pressure gradient across the gas exchanger was always <10 mm Hg. Maximum arteriovenous CO2 removal was 102.0 ± 9.5 mL/min (96{\%} of total CO2 production), allowing minute ventilation to be reduced from 10.3 ± 1.4 L/min (baseline) to 0.5 ± 0.0 L/min st 6 hrs of arteriovenous CO2 removal while maintaining normocapnia. Similarly, peak inspiratory pressure decreased from 40.8 ± 2.1 to 19.7 ± 7.5 cm H20. Pao2 was maintained at >100 torr (>13.3 kPa) at maximally reduced ventilator support. Mean arterial pressure and cardiac output did not change significantly as a result of arteriovenous shunting. Conclusions: Extracorporeal CO2 removal using a low- resistance gas exchanger in a simple arteriovenous shunt allows significant reduction in minute ventilation and peak inspiratory pressure without hypercapnia or the complex circuitry and monitoring required for conventional extracorporeal membrane oxygenation. Arteriovenous CO2 removal can be applied as an easy and cost-effective treatment to minimize ventilator- induced barotrauma and volutrauma during severe respiratory failure.",
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author = "Weike Tao and Brunston, {Robert L.} and Akhil Bidani and Philip Pirtle and James Dy and Cardenas, {Victor J.} and Traber, {Daniel L.} and Zwischenberger, {Joseph B.}",
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TY - JOUR

T1 - Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure

AU - Tao, Weike

AU - Brunston, Robert L.

AU - Bidani, Akhil

AU - Pirtle, Philip

AU - Dy, James

AU - Cardenas, Victor J.

AU - Traber, Daniel L.

AU - Zwischenberger, Joseph B.

PY - 1997

Y1 - 1997

N2 - Objectives: To quantify CO2 removal using an extracorporeal low- resistance membrane gas exchanger placed in an arteriovenous shunt and evaluate its effects on the reduction of ventilatory volumes and airway pressures during severe respiratory failure induced by smoke inhalation injury. Design: Prospective study. Setting: Research laboratory. Subjects: Adult female sheep (n = 5). Interventions: Animals were instrumented with femoral and pulmonary arterial catheters and underwent an LD50 cotton smoke inhalation injury via a tracheostomy under halothane anesthesia. Twenty-four hours after smoke inhalation injury, the animals were reanesthetized and systemically heparinized for cannulation of the left carotid artery end common jugular vein to construct a simple arteriovenous shunt. A membrane gas exchanger was interposed within the arteriovenous shunt, and blood flow produced by the arteriovenous pressure gradient was unrestricted at the time of complete recovery from anesthesia. CO2 removal by the gas exchanger was measured as the product of the sweep gas flow (FIO2 of 1.0 at 2.5 to 3.0 L/min) and the exhaust CO2 content measured with an inline capnometer. CO2 removed by the animal's lungs was determined by the expired gas CO2 content in a Douglas bag. We made stepwise, 20% reductions in ventilator support hourly. We first reduced the tidal volume to achieve a peak inspiratory pressure of <30 cm H2O, and then we reduced the respiratory rate while maintaining normocapnia. Pao2 was maintained by adjusting the FIO2 and the level of positive end-expiratory pressure. Measurements and Main Results: Mean blood flow through the arteriovenous shunt ranged from 1154 ± 82 mL/min (25% cardiac output) to 1277 ± 38 mL/min (29% cardiac output) over the 6-hr study period. The pressure gradient across the gas exchanger was always <10 mm Hg. Maximum arteriovenous CO2 removal was 102.0 ± 9.5 mL/min (96% of total CO2 production), allowing minute ventilation to be reduced from 10.3 ± 1.4 L/min (baseline) to 0.5 ± 0.0 L/min st 6 hrs of arteriovenous CO2 removal while maintaining normocapnia. Similarly, peak inspiratory pressure decreased from 40.8 ± 2.1 to 19.7 ± 7.5 cm H20. Pao2 was maintained at >100 torr (>13.3 kPa) at maximally reduced ventilator support. Mean arterial pressure and cardiac output did not change significantly as a result of arteriovenous shunting. Conclusions: Extracorporeal CO2 removal using a low- resistance gas exchanger in a simple arteriovenous shunt allows significant reduction in minute ventilation and peak inspiratory pressure without hypercapnia or the complex circuitry and monitoring required for conventional extracorporeal membrane oxygenation. Arteriovenous CO2 removal can be applied as an easy and cost-effective treatment to minimize ventilator- induced barotrauma and volutrauma during severe respiratory failure.

AB - Objectives: To quantify CO2 removal using an extracorporeal low- resistance membrane gas exchanger placed in an arteriovenous shunt and evaluate its effects on the reduction of ventilatory volumes and airway pressures during severe respiratory failure induced by smoke inhalation injury. Design: Prospective study. Setting: Research laboratory. Subjects: Adult female sheep (n = 5). Interventions: Animals were instrumented with femoral and pulmonary arterial catheters and underwent an LD50 cotton smoke inhalation injury via a tracheostomy under halothane anesthesia. Twenty-four hours after smoke inhalation injury, the animals were reanesthetized and systemically heparinized for cannulation of the left carotid artery end common jugular vein to construct a simple arteriovenous shunt. A membrane gas exchanger was interposed within the arteriovenous shunt, and blood flow produced by the arteriovenous pressure gradient was unrestricted at the time of complete recovery from anesthesia. CO2 removal by the gas exchanger was measured as the product of the sweep gas flow (FIO2 of 1.0 at 2.5 to 3.0 L/min) and the exhaust CO2 content measured with an inline capnometer. CO2 removed by the animal's lungs was determined by the expired gas CO2 content in a Douglas bag. We made stepwise, 20% reductions in ventilator support hourly. We first reduced the tidal volume to achieve a peak inspiratory pressure of <30 cm H2O, and then we reduced the respiratory rate while maintaining normocapnia. Pao2 was maintained by adjusting the FIO2 and the level of positive end-expiratory pressure. Measurements and Main Results: Mean blood flow through the arteriovenous shunt ranged from 1154 ± 82 mL/min (25% cardiac output) to 1277 ± 38 mL/min (29% cardiac output) over the 6-hr study period. The pressure gradient across the gas exchanger was always <10 mm Hg. Maximum arteriovenous CO2 removal was 102.0 ± 9.5 mL/min (96% of total CO2 production), allowing minute ventilation to be reduced from 10.3 ± 1.4 L/min (baseline) to 0.5 ± 0.0 L/min st 6 hrs of arteriovenous CO2 removal while maintaining normocapnia. Similarly, peak inspiratory pressure decreased from 40.8 ± 2.1 to 19.7 ± 7.5 cm H20. Pao2 was maintained at >100 torr (>13.3 kPa) at maximally reduced ventilator support. Mean arterial pressure and cardiac output did not change significantly as a result of arteriovenous shunting. Conclusions: Extracorporeal CO2 removal using a low- resistance gas exchanger in a simple arteriovenous shunt allows significant reduction in minute ventilation and peak inspiratory pressure without hypercapnia or the complex circuitry and monitoring required for conventional extracorporeal membrane oxygenation. Arteriovenous CO2 removal can be applied as an easy and cost-effective treatment to minimize ventilator- induced barotrauma and volutrauma during severe respiratory failure.

KW - acute respiratory failure

KW - adult respiratory distress syndrome

KW - barotrauma

KW - extracorporeal CO removal

KW - extracorporeal membrane oxygenation

KW - sheep

KW - ventilator

KW - volutrauma

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