Similarities and differences in host cell signaling following infection with different Rickettsia species.

Elena Rydkina, David J. Silverman, Sanjeev Sahni

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Signaling interactions between vascular endothelium and invading rickettsiae provide a unique way of coordinating appropriate physiologic responses, which are important determinants of the ensuing pathogenesis mechanisms such as host defense and inflammation. Two major subgroups of pathogenic Rickettsia species, namely the typhus group (TG) and the spotted fever group (SFG), exhibit marked differences in their intracytoplasmic behavior. Using in vitro infection of cultured human endothelial cells with R. rickettsii, the causative agent of Rocky Mountain SF, we previously identified activation of NF-kappaB and p38 MAP kinase as essential components of intracellular signaling events responsible for Rickettsia-induced transcriptional activation. Our data also suggest that p38 activity does not contribute to NF-kappaB response, implicating involvement of independent upstream signaling pathways. Since divergent cytopathologies suggest potentially different interactions with host cells, the aim of this study was to compare these responses after endothelial cell infection with R. conorii, the agent of Mediterranean SF, and a TG representative R. typhi, the agent of endemic typhus.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume1063
DOIs
StatePublished - Dec 2005
Externally publishedYes

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Cell signaling
Rickettsia
Epidemic Louse-Borne Typhus
NF-kappa B
Endothelial cells
Endothelial Cells
Endemic Flea-Borne Typhus
Infection
Chemical activation
Vascular Endothelium
p38 Mitogen-Activated Protein Kinases
Transcriptional Activation
Fever
Inflammation
Typhus
Cells
Activation
Interaction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Similarities and differences in host cell signaling following infection with different Rickettsia species. / Rydkina, Elena; Silverman, David J.; Sahni, Sanjeev.

In: Annals of the New York Academy of Sciences, Vol. 1063, 12.2005, p. 203-206.

Research output: Contribution to journalArticle

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