Similarity of Fibroglandular Breast Tissue Content Measured from Magnetic Resonance and Mammographic Images and by a Mathematical Algorithm

Fatima Nayeem, Hyunsu Ju, Donald G. Brunder, Manubai Nagamani, Karl Anderson, Tuenchit Khamapirad, Leejane Lu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Women with high breast density (BD) have a 4- to 6-fold greater risk for breast cancer than women with low BD. We found that BD can be easily computed from a mathematical algorithm using routine mammographic imaging data or by a curve-fitting algorithm using fat and nonfat suppression magnetic resonance imaging (MRI) data. These BD measures in a strictly defined group of premenopausal women providing both mammographic and breast MRI images were predicted as well by the same set of strong predictor variables as were measures from a published laborious histogram segmentation method and a full field digital mammographic unit in multivariate regression models. We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were more strongly associated with amounts of glandular tissue than adipose tissue, while fat body mass, alanine aminotransferase, and insulin like growth factor-II appear to be more associated with the amount of breast adipose tissue. Our results show that methods of breast imaging and modalities for estimating the amount of glandular tissue have no effects on the strength of these predictors of BD. Thus, the more convenient mathematical algorithm and the safer MRI protocols may facilitate prospective measurements of BD.

Original languageEnglish (US)
Article number961679
JournalInternational Journal of Breast Cancer
Volume2014
DOIs
StatePublished - 2014

Fingerprint

Breast
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Adipose Tissue
Insulin-Like Growth Factor II
Fat Body
Aspartate Aminotransferases
Alanine Transaminase
C-Reactive Protein
Progesterone
Breast Density
Fats
Breast Neoplasms
Pregnancy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)
  • Cancer Research

Cite this

Similarity of Fibroglandular Breast Tissue Content Measured from Magnetic Resonance and Mammographic Images and by a Mathematical Algorithm. / Nayeem, Fatima; Ju, Hyunsu; Brunder, Donald G.; Nagamani, Manubai; Anderson, Karl; Khamapirad, Tuenchit; Lu, Leejane.

In: International Journal of Breast Cancer, Vol. 2014, 961679, 2014.

Research output: Contribution to journalArticle

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