Simulated airplane flight increases plasma lactate in fetal rabbits

B. Schumacher, G. L. Olson, George Saade, C. N. Ou, T. E. Sutton, K. J. Moise, C. E. Fife

Research output: Contribution to journalArticlepeer-review


Schumacher B, Olson GL, Saade GR, Ou C-N, Sutton TE, Moise KJ Jr, Fife CE. Simulated airplane flight increases plasma lactate in fetal rabbits. Undersea Hyper Med 1999; 26(2):67-73. - We studied the effect of 9 h of simulated airplane cabin conditions at cruising altitude (8,000 feet; inspired oxygen equivalent to 15% O2 at sea level) on fetal plasma lactate in near-term pregnant rabbits. Controls (n = 19) spent 9 h at sea level (21% O2). Study group I (n = 21) experienced airplane cabin conditions. Study group II (n = 17) was studied at 8,000 feet with the inspired O2 concentration normalized to sea level. Study group in (n = 19) remained at sea level breathing 15% O2. Before ending each exposure, fetal blood sampling for lactate was performed under ultrasound guidance. Maternal lactates were obtained before and after sampling fetuses. Wilcoxon signed rank test, analysis of variance, and Bonferroni's method were used as appropriate. P < 0.05 denoted statistical significance. Study group I (altitude/hypoxia) had higher fetal lactates than controls (sea level/normoxia) and study group II (altitude/normoxia). Fetal lactates in study group I (altitude/hypoxia) were higher than in study group III (sea level/hypoxia). Maternal lactates were lower after fetal sampling. Fetal lactic acidemia was observed after 9 h of airplane cabin conditions. This was attributed to the combined effect of the lowered oxygen concentration and the decrease in atmospheric pressure.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalUndersea and Hyperbaric Medicine
Issue number2
StatePublished - Jun 1999


  • Altitude
  • Fetus
  • Hypoxia
  • Lactate
  • Rabbit

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology (medical)


Dive into the research topics of 'Simulated airplane flight increases plasma lactate in fetal rabbits'. Together they form a unique fingerprint.

Cite this