Simulator for simulating and monitoring the hypotensive patients blood pressure response of phenylephrine bolus injection and infusion with open-loop and closedloop treatment

Guoyan Cao, Tomas Luspay, Behrouz Ebrahimi, Karolos Grigoriadis, Matthew Franchek, Nicole Marques, Jordan Wolf, George Kramer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In this paper, we introduce a model-based simulator for hypotensive patients' blood pressure response to vasopressor drug phenylephrine (PHP) delivery. The simulator is designed based on a model of the mean arterial pressure (MAP) response to PHP infusion. The model is data-driven learning model which is illustrated to be adequately describing inter -And intra patients' response to PHP. In the simulator, besides open loop operation, such as manual PHP bolus injection and continuous infusion, a closed-loop control module is also designed, including an antiwindup PI controller, an adaptive controller and an empirical controller, to regulate the blood pressure at target level and maintain hemodynamic stability in hypotensive patients. In addition, three frequent scenarios happened in clinical treatment are modeled in challenge module. They are sodium nitroprusside (SNP) treatment, baseline pressure drop and hemorrhage. The simulator can be operated with two different interfaces; one is the MPA trend response interface and the other is real-Time monitoring interface. The real-Time monitoring is real-Time synchronization presenting blood pressure waves, heart rate and EtCO2 waves under open and closed-loop treatment. The simulator is capable to train the doctors on the dose of PHP usage for the hypotensive patients with different challenges during the treatment.

Original languageEnglish (US)
Title of host publicationProceedings of the 8th International Conference on Computer Modeling and Simulation, ICCMS 2017
PublisherAssociation for Computing Machinery
Pages175-181
Number of pages7
ISBN (Electronic)9781450348164
DOIs
StatePublished - Jan 20 2017
Event8th International Conference on Computer Modeling and Simulation, ICCMS 2017 - Canberra, Australia
Duration: Jan 20 2017Jan 23 2017

Publication series

NameACM International Conference Proceeding Series
VolumePart F128047

Other

Other8th International Conference on Computer Modeling and Simulation, ICCMS 2017
CountryAustralia
CityCanberra
Period1/20/171/23/17

Keywords

  • Blood pressure dynamic modeling
  • Closedloop infusion
  • Hypotensive patient
  • Phenylephrine drug delivery
  • Real-Time monitoring
  • Simulator

ASJC Scopus subject areas

  • Software
  • Human-Computer Interaction
  • Computer Vision and Pattern Recognition
  • Computer Networks and Communications

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  • Cite this

    Cao, G., Luspay, T., Ebrahimi, B., Grigoriadis, K., Franchek, M., Marques, N., Wolf, J., & Kramer, G. (2017). Simulator for simulating and monitoring the hypotensive patients blood pressure response of phenylephrine bolus injection and infusion with open-loop and closedloop treatment. In Proceedings of the 8th International Conference on Computer Modeling and Simulation, ICCMS 2017 (pp. 175-181). (ACM International Conference Proceeding Series; Vol. Part F128047). Association for Computing Machinery. https://doi.org/10.1145/3036331.3036341