Simultaneous Congenital Infection with Epstein–Barr Virus and Cytomegalovirus

WE have previously reported the persistence of the cytomegalovirus (CMV) genome in lymphoid cells in long-term cultures from an infant with congenital CMV infection.^1,2 The Epstein–Barr virus (EBV) genome was also present in these cells, but the presence of congenital EBV infection was merely presumed on the basis of serologic evidence, since blood for the spontaneous establishment of a lymphoblastoid cell line in this instance was not available from the infant until three months after birth. We have now studied another infant, born to a primigravida mother, who had clinical, laboratory, and pathological evidence of congenital CMV infection at birth.