TY - JOUR
T1 - Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults
AU - Markofski, Melissa M.
AU - Jennings, Kristofer
AU - Dolan, Chad
AU - Davies, Natalie A.
AU - LaVoy, Emily C.
AU - Ryan, Edward J.
AU - Carrillo, Andres E.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: MMM: Authorship of this article was partially supported by funding from by the National Cancer Institute of the National Institutes of Health under Award Number P20CA221697, P20CA221696, and P20CA221696S1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The sponsor did not play a role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. https://www.cancer.gov
Publisher Copyright:
© 2019 The Author(s).
PY - 2021/11
Y1 - 2021/11
N2 - The paleo diet is popular among the general population due to promoted weight loss and disease prevention benefits. We examined the effectiveness of a self-administered paleo diet in improving cardiometabolic disease risk factors. Overweight, physically inactive but otherwise healthy adults (males = 4, females = 3, age 32.7 ± 4.9 years, body mass index [BMI] 29.4 ± 2.4 kg/m2) habitually eating a traditional Western diet (1853.4 ± 441.2 kcal; 34.0% carbohydrate; 41.4% fat; 19.2% protein) completed an ad libitum self-administered paleo diet for 8 weeks. Height, weight, blood pressure, and a fasting blood sample were collected pre– and post–paleo dietary intervention. Blood samples were analyzed for fasting cardiometabolic disease biomarkers—including brain-derived neurotropic factor (BDNF), fibroblast growth factor (FGF) 21, and leptin. After 8 weeks, body mass (−5.3 kg, P =.008), BMI (−1.7 kg/m2, P =.002), serum leptin (−56.2%, P =.012), serum FGF21 (−26.7%, P =.002), and serum BDNF (−25.8%, P =.045) significantly decreased. Systolic and diastolic blood pressure were unchanged following the paleo dietary intervention (P >.05). Average energy intake (−412.6 kcal, P =.016) significantly decreased with the paleo dietary intervention mostly due to a reduction in carbohydrate consumption (−69.2 g; P =.003). An 8-week self-administered paleo dietary intervention was effective in improving cardiometabolic disease risk factors in a healthy, physically inactive overweight adult population.
AB - The paleo diet is popular among the general population due to promoted weight loss and disease prevention benefits. We examined the effectiveness of a self-administered paleo diet in improving cardiometabolic disease risk factors. Overweight, physically inactive but otherwise healthy adults (males = 4, females = 3, age 32.7 ± 4.9 years, body mass index [BMI] 29.4 ± 2.4 kg/m2) habitually eating a traditional Western diet (1853.4 ± 441.2 kcal; 34.0% carbohydrate; 41.4% fat; 19.2% protein) completed an ad libitum self-administered paleo diet for 8 weeks. Height, weight, blood pressure, and a fasting blood sample were collected pre– and post–paleo dietary intervention. Blood samples were analyzed for fasting cardiometabolic disease biomarkers—including brain-derived neurotropic factor (BDNF), fibroblast growth factor (FGF) 21, and leptin. After 8 weeks, body mass (−5.3 kg, P =.008), BMI (−1.7 kg/m2, P =.002), serum leptin (−56.2%, P =.012), serum FGF21 (−26.7%, P =.002), and serum BDNF (−25.8%, P =.045) significantly decreased. Systolic and diastolic blood pressure were unchanged following the paleo dietary intervention (P >.05). Average energy intake (−412.6 kcal, P =.016) significantly decreased with the paleo dietary intervention mostly due to a reduction in carbohydrate consumption (−69.2 g; P =.003). An 8-week self-administered paleo dietary intervention was effective in improving cardiometabolic disease risk factors in a healthy, physically inactive overweight adult population.
KW - dietary intervention
KW - inflammation
KW - metabolic syndrome
KW - young adults
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U2 - 10.1177/1559827619866157
DO - 10.1177/1559827619866157
M3 - Article
AN - SCOPUS:85070290620
VL - 15
SP - 690
EP - 700
JO - American Journal of Lifestyle Medicine
JF - American Journal of Lifestyle Medicine
SN - 1559-8276
IS - 6
ER -