Abstract
The paleo diet is popular among the general population due to promoted weight loss and disease prevention benefits. We examined the effectiveness of a self-administered paleo diet in improving cardiometabolic disease risk factors. Overweight, physically inactive but otherwise healthy adults (males = 4, females = 3, age 32.7 ± 4.9 years, body mass index [BMI] 29.4 ± 2.4 kg/m2) habitually eating a traditional Western diet (1853.4 ± 441.2 kcal; 34.0% carbohydrate; 41.4% fat; 19.2% protein) completed an ad libitum self-administered paleo diet for 8 weeks. Height, weight, blood pressure, and a fasting blood sample were collected pre– and post–paleo dietary intervention. Blood samples were analyzed for fasting cardiometabolic disease biomarkers—including brain-derived neurotropic factor (BDNF), fibroblast growth factor (FGF) 21, and leptin. After 8 weeks, body mass (−5.3 kg, P =.008), BMI (−1.7 kg/m2, P =.002), serum leptin (−56.2%, P =.012), serum FGF21 (−26.7%, P =.002), and serum BDNF (−25.8%, P =.045) significantly decreased. Systolic and diastolic blood pressure were unchanged following the paleo dietary intervention (P >.05). Average energy intake (−412.6 kcal, P =.016) significantly decreased with the paleo dietary intervention mostly due to a reduction in carbohydrate consumption (−69.2 g; P =.003). An 8-week self-administered paleo dietary intervention was effective in improving cardiometabolic disease risk factors in a healthy, physically inactive overweight adult population.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Lifestyle Medicine |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- dietary intervention
- inflammation
- metabolic syndrome
- young adults
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Health Policy
- Public Health, Environmental and Occupational Health
Cite this
Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults. / Markofski, Melissa M.; Jennings, Kristofer; Dolan, Chad; Davies, Natalie A.; LaVoy, Emily C.; Ryan, Edward J.; Carrillo, Andres E.
In: American Journal of Lifestyle Medicine, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults
AU - Markofski, Melissa M.
AU - Jennings, Kristofer
AU - Dolan, Chad
AU - Davies, Natalie A.
AU - LaVoy, Emily C.
AU - Ryan, Edward J.
AU - Carrillo, Andres E.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The paleo diet is popular among the general population due to promoted weight loss and disease prevention benefits. We examined the effectiveness of a self-administered paleo diet in improving cardiometabolic disease risk factors. Overweight, physically inactive but otherwise healthy adults (males = 4, females = 3, age 32.7 ± 4.9 years, body mass index [BMI] 29.4 ± 2.4 kg/m2) habitually eating a traditional Western diet (1853.4 ± 441.2 kcal; 34.0% carbohydrate; 41.4% fat; 19.2% protein) completed an ad libitum self-administered paleo diet for 8 weeks. Height, weight, blood pressure, and a fasting blood sample were collected pre– and post–paleo dietary intervention. Blood samples were analyzed for fasting cardiometabolic disease biomarkers—including brain-derived neurotropic factor (BDNF), fibroblast growth factor (FGF) 21, and leptin. After 8 weeks, body mass (−5.3 kg, P =.008), BMI (−1.7 kg/m2, P =.002), serum leptin (−56.2%, P =.012), serum FGF21 (−26.7%, P =.002), and serum BDNF (−25.8%, P =.045) significantly decreased. Systolic and diastolic blood pressure were unchanged following the paleo dietary intervention (P >.05). Average energy intake (−412.6 kcal, P =.016) significantly decreased with the paleo dietary intervention mostly due to a reduction in carbohydrate consumption (−69.2 g; P =.003). An 8-week self-administered paleo dietary intervention was effective in improving cardiometabolic disease risk factors in a healthy, physically inactive overweight adult population.
AB - The paleo diet is popular among the general population due to promoted weight loss and disease prevention benefits. We examined the effectiveness of a self-administered paleo diet in improving cardiometabolic disease risk factors. Overweight, physically inactive but otherwise healthy adults (males = 4, females = 3, age 32.7 ± 4.9 years, body mass index [BMI] 29.4 ± 2.4 kg/m2) habitually eating a traditional Western diet (1853.4 ± 441.2 kcal; 34.0% carbohydrate; 41.4% fat; 19.2% protein) completed an ad libitum self-administered paleo diet for 8 weeks. Height, weight, blood pressure, and a fasting blood sample were collected pre– and post–paleo dietary intervention. Blood samples were analyzed for fasting cardiometabolic disease biomarkers—including brain-derived neurotropic factor (BDNF), fibroblast growth factor (FGF) 21, and leptin. After 8 weeks, body mass (−5.3 kg, P =.008), BMI (−1.7 kg/m2, P =.002), serum leptin (−56.2%, P =.012), serum FGF21 (−26.7%, P =.002), and serum BDNF (−25.8%, P =.045) significantly decreased. Systolic and diastolic blood pressure were unchanged following the paleo dietary intervention (P >.05). Average energy intake (−412.6 kcal, P =.016) significantly decreased with the paleo dietary intervention mostly due to a reduction in carbohydrate consumption (−69.2 g; P =.003). An 8-week self-administered paleo dietary intervention was effective in improving cardiometabolic disease risk factors in a healthy, physically inactive overweight adult population.
KW - dietary intervention
KW - inflammation
KW - metabolic syndrome
KW - young adults
UR - http://www.scopus.com/inward/record.url?scp=85070290620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070290620&partnerID=8YFLogxK
U2 - 10.1177/1559827619866157
DO - 10.1177/1559827619866157
M3 - Article
JO - American Journal of Lifestyle Medicine
JF - American Journal of Lifestyle Medicine
SN - 1559-8276
ER -