Abstract
Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide on the energy metabolism. Animals received a single or daily injection of saline or liraglutide during 7 days (25, 50, 100, or 300 μg/kg i.p.). Twenty-four hours after the single or last injection, the rats were euthanized and the hypothalamus, prefrontal cortex, cerebellum, hippocampus, striatum, and posterior cortex were isolated. Our results demonstrated that a single dose of liraglutide in young rats increased the activity of complexes and inhibited creatine kinase activity. Repeated administrations of liraglutide in young rats reduced the activity of complexes and activated creatine kinase activity. In adult rats, a single dose of liraglutide reduced the activity of complex I and creatine kinase and increased the activity of complexes II and IV. Repeated administrations of liraglutide in adult rats increased the activity of complexes I and IV and reduced the activity of complex II and creatine kinase. We concluded that liraglutide may interfere in energy metabolism, because analysis of different times of administrations, concentrations, and level of brain development leads to divergent results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 451-458 |
| Number of pages | 8 |
| Journal | Biochemistry and Cell Biology |
| Volume | 94 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 3 2016 |
| Externally published | Yes |
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Keywords
- Energy metabolism
- GLP-1
- Incretin system
- Liraglutide
- Obesity
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
Single dose and repeated administrations of liraglutide alter energy metabolism in the brains of young and adult rats. / Prá, Morgana; Ferreira, Gabriela Kozuchovski; Haas de Mello, Aline; Schraiber, Rosiane De Bona; Cardoso, Larissa Colonetti; Souza, Luana Da Rosa; Da Rosa, Naiana; Fortunato, Jucélia Jeremias; Rezin, Gislaine Tezza.
In: Biochemistry and Cell Biology, Vol. 94, No. 5, 03.05.2016, p. 451-458.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single dose and repeated administrations of liraglutide alter energy metabolism in the brains of young and adult rats
AU - Prá, Morgana
AU - Ferreira, Gabriela Kozuchovski
AU - Haas de Mello, Aline
AU - Schraiber, Rosiane De Bona
AU - Cardoso, Larissa Colonetti
AU - Souza, Luana Da Rosa
AU - Da Rosa, Naiana
AU - Fortunato, Jucélia Jeremias
AU - Rezin, Gislaine Tezza
PY - 2016/5/3
Y1 - 2016/5/3
N2 - Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide on the energy metabolism. Animals received a single or daily injection of saline or liraglutide during 7 days (25, 50, 100, or 300 μg/kg i.p.). Twenty-four hours after the single or last injection, the rats were euthanized and the hypothalamus, prefrontal cortex, cerebellum, hippocampus, striatum, and posterior cortex were isolated. Our results demonstrated that a single dose of liraglutide in young rats increased the activity of complexes and inhibited creatine kinase activity. Repeated administrations of liraglutide in young rats reduced the activity of complexes and activated creatine kinase activity. In adult rats, a single dose of liraglutide reduced the activity of complex I and creatine kinase and increased the activity of complexes II and IV. Repeated administrations of liraglutide in adult rats increased the activity of complexes I and IV and reduced the activity of complex II and creatine kinase. We concluded that liraglutide may interfere in energy metabolism, because analysis of different times of administrations, concentrations, and level of brain development leads to divergent results.
AB - Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide on the energy metabolism. Animals received a single or daily injection of saline or liraglutide during 7 days (25, 50, 100, or 300 μg/kg i.p.). Twenty-four hours after the single or last injection, the rats were euthanized and the hypothalamus, prefrontal cortex, cerebellum, hippocampus, striatum, and posterior cortex were isolated. Our results demonstrated that a single dose of liraglutide in young rats increased the activity of complexes and inhibited creatine kinase activity. Repeated administrations of liraglutide in young rats reduced the activity of complexes and activated creatine kinase activity. In adult rats, a single dose of liraglutide reduced the activity of complex I and creatine kinase and increased the activity of complexes II and IV. Repeated administrations of liraglutide in adult rats increased the activity of complexes I and IV and reduced the activity of complex II and creatine kinase. We concluded that liraglutide may interfere in energy metabolism, because analysis of different times of administrations, concentrations, and level of brain development leads to divergent results.
KW - Energy metabolism
KW - GLP-1
KW - Incretin system
KW - Liraglutide
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84991082258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991082258&partnerID=8YFLogxK
U2 - 10.1139/bcb-2016-0016
DO - 10.1139/bcb-2016-0016
M3 - Article
C2 - 27563837
AN - SCOPUS:84991082258
VL - 94
SP - 451
EP - 458
JO - Biochemistry and Cell Biology
JF - Biochemistry and Cell Biology
SN - 0829-8211
IS - 5
ER -