Sinonasal Hemangiopericytomas: A Clinicopathologic and DNA Content Study

Adel K. Naggar; John G. Batsakis; Glenn M. Garcia; Mario L. Luna; Helmuth Goepfert

doi:10.1001/archotol.1992.01880020026010

Sinonasal Hemangiopericytomas: A Clinicopathologic and DNA Content Study

Adel K. Naggar, John G. Batsakis, Glenn M. Garcia, Mario L. Luna, Helmuth Goepfert

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The clinicopathologic and the flow cytometric DNA characteristics of 14 patients with sinonasal hemangiopericytomas are presented. Patient and tumor characteristics were similar to previously published series. Flow cytometric analysis revealed a diploid DNA pattern and low S-phase in 13 neoplasms and an aneuploid DNA pattern with relatively high S-phase in one. Histopathologically, all diploid and low S-phase neoplasms displayed relatively uniform cellular features and low mitotic counts. All patients are alive and free of disease; one is still alive after a single recurrence. Our data suggest that sinonasal hemangiopericytomas are low-grade neoplasms as evidenced by their histomorphology and their DNA content. Recurrences are delayed and can be controlled.

Original language	English (US)
Pages (from-to)	134-137
Number of pages	4
Journal	Archives of Otolaryngology--Head and Neck Surgery
Volume	118
Issue number	2
DOIs	https://doi.org/10.1001/archotol.1992.01880020026010
State	Published - Feb 1992
Externally published	Yes

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1001/archotol.1992.01880020026010

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title = "Sinonasal Hemangiopericytomas: A Clinicopathologic and DNA Content Study",

abstract = "The clinicopathologic and the flow cytometric DNA characteristics of 14 patients with sinonasal hemangiopericytomas are presented. Patient and tumor characteristics were similar to previously published series. Flow cytometric analysis revealed a diploid DNA pattern and low S-phase in 13 neoplasms and an aneuploid DNA pattern with relatively high S-phase in one. Histopathologically, all diploid and low S-phase neoplasms displayed relatively uniform cellular features and low mitotic counts. All patients are alive and free of disease; one is still alive after a single recurrence. Our data suggest that sinonasal hemangiopericytomas are low-grade neoplasms as evidenced by their histomorphology and their DNA content. Recurrences are delayed and can be controlled.",

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AU - Naggar, Adel K.

AU - Batsakis, John G.

AU - Garcia, Glenn M.

AU - Luna, Mario L.

AU - Goepfert, Helmuth

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AB - The clinicopathologic and the flow cytometric DNA characteristics of 14 patients with sinonasal hemangiopericytomas are presented. Patient and tumor characteristics were similar to previously published series. Flow cytometric analysis revealed a diploid DNA pattern and low S-phase in 13 neoplasms and an aneuploid DNA pattern with relatively high S-phase in one. Histopathologically, all diploid and low S-phase neoplasms displayed relatively uniform cellular features and low mitotic counts. All patients are alive and free of disease; one is still alive after a single recurrence. Our data suggest that sinonasal hemangiopericytomas are low-grade neoplasms as evidenced by their histomorphology and their DNA content. Recurrences are delayed and can be controlled.

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Sinonasal Hemangiopericytomas: A Clinicopathologic and DNA Content Study

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