Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez; Marcio R.T. Nunes; Hilda Guzman; Sandra Uribe; Juan Carlos Gallego Gómez; Juan David Suaza Vasco; Jedson F. Cardoso; Vsevolod L. Popov; Steven G. Widen; Thomas G. Wood; Nikos Vasilakis; Robert B. Tesh

doi:10.1016/j.virol.2016.11.014

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez, Marcio R.T. Nunes, Hilda Guzman, Sandra Uribe, Juan Carlos Gallego Gómez, Juan David Suaza Vasco, Jedson F. Cardoso, Vsevolod L. Popov, Steven G. Widen, Thomas G. Wood, Nikos Vasilakis, Robert B. Tesh

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

Original language	English (US)
Pages (from-to)	166-175
Number of pages	10
Journal	Virology
Volume	501
DOIs	https://doi.org/10.1016/j.virol.2016.11.014
State	Published - Jan 15 2017

Keywords

Insect-specific viruses
Orthomyxoviridae
Sinu virus
Thogotovirus genus

ASJC Scopus subject areas

Virology

Access to Document

10.1016/j.virol.2016.11.014

Cite this

Contreras-Gutiérrez, M. A., Nunes, M. R. T., Guzman, H., Uribe, S., Gallego Gómez, J. C., Suaza Vasco, J. D., Cardoso, J. F., Popov, V. L., Widen, S. G., Wood, T. G., Vasilakis, N., & Tesh, R. B. (2017). Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, 501, 166-175. https://doi.org/10.1016/j.virol.2016.11.014

Contreras-Gutiérrez, MA, Nunes, MRT, Guzman, H, Uribe, S, Gallego Gómez, JC, Suaza Vasco, JD, Cardoso, JF, Popov, VL, Widen, SG, Wood, TG, Vasilakis, N & Tesh, RB 2017, 'Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia', Virology, vol. 501, pp. 166-175. https://doi.org/10.1016/j.virol.2016.11.014

@article{2e28795cd6a0470fb335e172ebb3df1a,

title = "Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia",

abstract = "The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.",

keywords = "Insect-specific viruses, Orthomyxoviridae, Sinu virus, Thogotovirus genus",

author = "Contreras-Guti{\'e}rrez, {Mar{\'i}a Ang{\'e}lica} and Nunes, {Marcio R.T.} and Hilda Guzman and Sandra Uribe and {Gallego G{\'o}mez}, {Juan Carlos} and {Suaza Vasco}, {Juan David} and Cardoso, {Jedson F.} and Popov, {Vsevolod L.} and Widen, {Steven G.} and Wood, {Thomas G.} and Nikos Vasilakis and Tesh, {Robert B.}",

note = "Publisher Copyright: {\textcopyright} 2016",

year = "2017",

month = jan,

day = "15",

doi = "10.1016/j.virol.2016.11.014",

language = "English (US)",

volume = "501",

pages = "166--175",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

AU - Contreras-Gutiérrez, María Angélica

AU - Nunes, Marcio R.T.

AU - Guzman, Hilda

AU - Uribe, Sandra

AU - Gallego Gómez, Juan Carlos

AU - Suaza Vasco, Juan David

AU - Cardoso, Jedson F.

AU - Popov, Vsevolod L.

AU - Widen, Steven G.

AU - Wood, Thomas G.

AU - Vasilakis, Nikos

AU - Tesh, Robert B.

PY - 2017/1/15

Y1 - 2017/1/15

N2 - The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

AB - The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

KW - Insect-specific viruses

KW - Orthomyxoviridae

KW - Sinu virus

KW - Thogotovirus genus

UR - http://www.scopus.com/inward/record.url?scp=85002202550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85002202550&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2016.11.014

DO - 10.1016/j.virol.2016.11.014

M3 - Article

C2 - 27936462

AN - SCOPUS:85002202550

SN - 0042-6822

VL - 501

SP - 166

EP - 175

JO - Virology

JF - Virology

ER -

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this