Abstract
The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 166-175 |
| Number of pages | 10 |
| Journal | Virology |
| Volume | 501 |
| DOIs | |
| State | Published - Jan 15 2017 |
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Keywords
- Insect-specific viruses
- Orthomyxoviridae
- Sinu virus
- Thogotovirus genus
ASJC Scopus subject areas
- Virology
Cite this
Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. / Contreras-Gutiérrez, María Angélica; Nunes, Marcio R T; Guzman, Hilda; Uribe, Sandra; Gallego Gómez, Juan Carlos; Suaza Vasco, Juan David; Cardoso, Jedson F.; Popov, Vsevolod; Widen, Steven; Wood, Thomas; Vasilakis, Nikos; Tesh, Robert B.
In: Virology, Vol. 501, 15.01.2017, p. 166-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia
AU - Contreras-Gutiérrez, María Angélica
AU - Nunes, Marcio R T
AU - Guzman, Hilda
AU - Uribe, Sandra
AU - Gallego Gómez, Juan Carlos
AU - Suaza Vasco, Juan David
AU - Cardoso, Jedson F.
AU - Popov, Vsevolod
AU - Widen, Steven
AU - Wood, Thomas
AU - Vasilakis, Nikos
AU - Tesh, Robert B.
PY - 2017/1/15
Y1 - 2017/1/15
N2 - The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
AB - The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
KW - Insect-specific viruses
KW - Orthomyxoviridae
KW - Sinu virus
KW - Thogotovirus genus
UR - http://www.scopus.com/inward/record.url?scp=85002202550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85002202550&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2016.11.014
DO - 10.1016/j.virol.2016.11.014
M3 - Article
VL - 501
SP - 166
EP - 175
JO - Virology
JF - Virology
SN - 0042-6822
ER -