Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez, Marcio R T Nunes, Hilda Guzman, Sandra Uribe, Juan Carlos Gallego Gómez, Juan David Suaza Vasco, Jedson F. Cardoso, Vsevolod Popov, Steven Widen, Thomas Wood, Nikos Vasilakis, Robert B. Tesh

Research output: Contribution to journalArticle

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Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

Original languageEnglish (US)
Pages (from-to)166-175
Number of pages10
JournalVirology
Volume501
DOIs
StatePublished - Jan 15 2017

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Thogotovirus
Colombia
Orthomyxoviridae
Culicidae
Viruses
Genes
Open Reading Frames
Insects
Genome

Keywords

  • Insect-specific viruses
  • Orthomyxoviridae
  • Sinu virus
  • Thogotovirus genus

ASJC Scopus subject areas

  • Virology

Cite this

Contreras-Gutiérrez, M. A., Nunes, M. R. T., Guzman, H., Uribe, S., Gallego Gómez, J. C., Suaza Vasco, J. D., ... Tesh, R. B. (2017). Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, 501, 166-175. https://doi.org/10.1016/j.virol.2016.11.014

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. / Contreras-Gutiérrez, María Angélica; Nunes, Marcio R T; Guzman, Hilda; Uribe, Sandra; Gallego Gómez, Juan Carlos; Suaza Vasco, Juan David; Cardoso, Jedson F.; Popov, Vsevolod; Widen, Steven; Wood, Thomas; Vasilakis, Nikos; Tesh, Robert B.

In: Virology, Vol. 501, 15.01.2017, p. 166-175.

Research output: Contribution to journalArticle

Contreras-Gutiérrez, MA, Nunes, MRT, Guzman, H, Uribe, S, Gallego Gómez, JC, Suaza Vasco, JD, Cardoso, JF, Popov, V, Widen, S, Wood, T, Vasilakis, N & Tesh, RB 2017, 'Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia', Virology, vol. 501, pp. 166-175. https://doi.org/10.1016/j.virol.2016.11.014
Contreras-Gutiérrez MA, Nunes MRT, Guzman H, Uribe S, Gallego Gómez JC, Suaza Vasco JD et al. Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology. 2017 Jan 15;501:166-175. https://doi.org/10.1016/j.virol.2016.11.014
Contreras-Gutiérrez, María Angélica ; Nunes, Marcio R T ; Guzman, Hilda ; Uribe, Sandra ; Gallego Gómez, Juan Carlos ; Suaza Vasco, Juan David ; Cardoso, Jedson F. ; Popov, Vsevolod ; Widen, Steven ; Wood, Thomas ; Vasilakis, Nikos ; Tesh, Robert B. / Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. In: Virology. 2017 ; Vol. 501. pp. 166-175.
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