Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez, Marcio R T Nunes, Hilda Guzman, Sandra Uribe, Juan Carlos Gallego Gómez, Juan David Suaza Vasco, Jedson F. Cardoso, Vsevolod Popov, Steven Widen, Thomas Wood, Nikos Vasilakis, Robert B. Tesh

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

Original languageEnglish (US)
Pages (from-to)166-175
Number of pages10
JournalVirology
Volume501
DOIs
StatePublished - Jan 15 2017

    Fingerprint

Keywords

  • Insect-specific viruses
  • Orthomyxoviridae
  • Sinu virus
  • Thogotovirus genus

ASJC Scopus subject areas

  • Virology

Cite this

Contreras-Gutiérrez, M. A., Nunes, M. R. T., Guzman, H., Uribe, S., Gallego Gómez, J. C., Suaza Vasco, J. D., Cardoso, J. F., Popov, V., Widen, S., Wood, T., Vasilakis, N., & Tesh, R. B. (2017). Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, 501, 166-175. https://doi.org/10.1016/j.virol.2016.11.014