Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez; Marcio R T Nunes; Hilda Guzman; Sandra Uribe; Juan Carlos Gallego Gómez; Juan David Suaza Vasco; Jedson F. Cardoso; Vsevolod Popov; Steven Widen; Thomas Wood; Nikos Vasilakis; Robert B. Tesh

doi:10.1016/j.virol.2016.11.014

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez, Marcio R T Nunes, Hilda Guzman, Sandra Uribe, Juan Carlos Gallego Gómez, Juan David Suaza Vasco, Jedson F. Cardoso, Vsevolod Popov, Steven Widen, Thomas Wood, Nikos Vasilakis, Robert B. Tesh

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

Original language	English (US)
Pages (from-to)	166-175
Number of pages	10
Journal	Virology
Volume	501
DOIs	https://doi.org/10.1016/j.virol.2016.11.014
State	Published - Jan 15 2017

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Keywords

Insect-specific viruses
Orthomyxoviridae
Sinu virus
Thogotovirus genus

ASJC Scopus subject areas

Virology

Cite this

Contreras-Gutiérrez, M. A., Nunes, M. R. T., Guzman, H., Uribe, S., Gallego Gómez, J. C., Suaza Vasco, J. D., Cardoso, J. F., Popov, V., Widen, S., Wood, T., Vasilakis, N., & Tesh, R. B. (2017). Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, 501, 166-175. https://doi.org/10.1016/j.virol.2016.11.014

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. / Contreras-Gutiérrez, María Angélica; Nunes, Marcio R T; Guzman, Hilda; Uribe, Sandra; Gallego Gómez, Juan Carlos; Suaza Vasco, Juan David; Cardoso, Jedson F.; Popov, Vsevolod ; Widen, Steven; Wood, Thomas; Vasilakis, Nikos; Tesh, Robert B.

In: Virology, Vol. 501, 15.01.2017, p. 166-175.

Research output: Contribution to journal › Article

Contreras-Gutiérrez, MA, Nunes, MRT, Guzman, H, Uribe, S, Gallego Gómez, JC, Suaza Vasco, JD, Cardoso, JF, Popov, V , Widen, S, Wood, T, Vasilakis, N & Tesh, RB 2017, 'Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia', Virology, vol. 501, pp. 166-175. https://doi.org/10.1016/j.virol.2016.11.014

Contreras-Gutiérrez, María Angélica ; Nunes, Marcio R T ; Guzman, Hilda ; Uribe, Sandra ; Gallego Gómez, Juan Carlos ; Suaza Vasco, Juan David ; Cardoso, Jedson F. ; Popov, Vsevolod ; Widen, Steven ; Wood, Thomas ; Vasilakis, Nikos ; Tesh, Robert B. / Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. In: Virology. 2017 ; Vol. 501. pp. 166-175.

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abstract = "The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.",

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10.1016/j.virol.2016.11.014