Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez, Marcio R.T. Nunes, Hilda Guzman, Sandra Uribe, Juan Carlos Gallego Gómez, Juan David Suaza Vasco, Jedson F. Cardoso, Vsevolod L. Popov, Steven G. Widen, Thomas G. Wood, Nikos Vasilakis, Robert B. Tesh

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

Original languageEnglish (US)
Pages (from-to)166-175
Number of pages10
JournalVirology
Volume501
DOIs
StatePublished - Jan 15 2017

Keywords

  • Insect-specific viruses
  • Orthomyxoviridae
  • Sinu virus
  • Thogotovirus genus

ASJC Scopus subject areas

  • Virology

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    Contreras-Gutiérrez, M. A., Nunes, M. R. T., Guzman, H., Uribe, S., Gallego Gómez, J. C., Suaza Vasco, J. D., Cardoso, J. F., Popov, V. L., Widen, S. G., Wood, T. G., Vasilakis, N., & Tesh, R. B. (2017). Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, 501, 166-175. https://doi.org/10.1016/j.virol.2016.11.014