Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez; Marcio R.T. Nunes; Hilda Guzman; Sandra Uribe; Juan Carlos Gallego Gómez; Juan David Suaza Vasco; Jedson F. Cardoso; Vsevolod L. Popov; Steven G. Widen; Thomas G. Wood; Nikos Vasilakis; Robert B. Tesh

doi:10.1016/j.virol.2016.11.014

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez, Marcio R.T. Nunes, Hilda Guzman, Sandra Uribe, Juan Carlos Gallego Gómez, Juan David Suaza Vasco, Jedson F. Cardoso, Vsevolod L. Popov, Steven G. Widen, Thomas G. Wood, Nikos Vasilakis, Robert B. Tesh

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

Original language	English (US)
Pages (from-to)	166-175
Number of pages	10
Journal	Virology
Volume	501
DOIs	https://doi.org/10.1016/j.virol.2016.11.014
State	Published - Jan 15 2017

Keywords

Insect-specific viruses
Orthomyxoviridae
Sinu virus
Thogotovirus genus

ASJC Scopus subject areas

Virology

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Contreras-Gutiérrez, M. A., Nunes, M. R. T., Guzman, H., Uribe, S., Gallego Gómez, J. C., Suaza Vasco, J. D., Cardoso, J. F., Popov, V. L., Widen, S. G., Wood, T. G., Vasilakis, N., & Tesh, R. B. (2017). Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, 501, 166-175. https://doi.org/10.1016/j.virol.2016.11.014

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. / Contreras-Gutiérrez, María Angélica; Nunes, Marcio R.T.; Guzman, Hilda; Uribe, Sandra; Gallego Gómez, Juan Carlos; Suaza Vasco, Juan David; Cardoso, Jedson F.; Popov, Vsevolod L.; Widen, Steven G.; Wood, Thomas G.; Vasilakis, Nikos; Tesh, Robert B.

In: Virology, Vol. 501, 15.01.2017, p. 166-175.

Research output: Contribution to journal › Article

Contreras-Gutiérrez, MA, Nunes, MRT, Guzman, H, Uribe, S, Gallego Gómez, JC, Suaza Vasco, JD, Cardoso, JF, Popov, VL , Widen, SG, Wood, TG, Vasilakis, N & Tesh, RB 2017, 'Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia', Virology, vol. 501, pp. 166-175. https://doi.org/10.1016/j.virol.2016.11.014

Contreras-Gutiérrez, María Angélica ; Nunes, Marcio R.T. ; Guzman, Hilda ; Uribe, Sandra ; Gallego Gómez, Juan Carlos ; Suaza Vasco, Juan David ; Cardoso, Jedson F. ; Popov, Vsevolod L. ; Widen, Steven G. ; Wood, Thomas G. ; Vasilakis, Nikos ; Tesh, Robert B. / Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. In: Virology. 2017 ; Vol. 501. pp. 166-175.

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abstract = "The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.",

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AU - Guzman, Hilda

AU - Uribe, Sandra

AU - Gallego Gómez, Juan Carlos

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AU - Cardoso, Jedson F.

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AU - Vasilakis, Nikos

AU - Tesh, Robert B.

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