Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez; Marcio R.T. Nunes; Hilda Guzman; Sandra Uribe; Juan Carlos Gallego Gómez; Juan David Suaza Vasco; Jedson F. Cardoso; Vsevolod L. Popov; Steven G. Widen; Thomas G. Wood; Nikos Vasilakis; Robert B. Tesh

doi:10.1016/j.virol.2016.11.014

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

María Angélica Contreras-Gutiérrez
, Marcio R.T. Nunes
, Hilda Guzman
, Sandra Uribe
, Juan Carlos Gallego Gómez
, Juan David Suaza Vasco
, Jedson F. Cardoso
, Vsevolod L. Popov
, Steven G. Widen
, Thomas G. Wood
, Nikos Vasilakis
, Robert B. Tesh

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

Original language	English (US)
Pages (from-to)	166-175
Number of pages	10
Journal	Virology
Volume	501
DOIs	https://doi.org/10.1016/j.virol.2016.11.014
State	Published - Jan 15 2017

Keywords

Insect-specific viruses
Orthomyxoviridae
Sinu virus
Thogotovirus genus

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2016.11.014

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Contreras-Gutiérrez, M. A., Nunes, M. R. T., Guzman, H., Uribe, S., Gallego Gómez, J. C., Suaza Vasco, J. D., Cardoso, J. F., Popov, V. L., Widen, S. G., Wood, T. G., Vasilakis, N., & Tesh, R. B. (2017). Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, 501, 166-175. https://doi.org/10.1016/j.virol.2016.11.014

Contreras-Gutiérrez, MA, Nunes, MRT, Guzman, H, Uribe, S, Gallego Gómez, JC, Suaza Vasco, JD, Cardoso, JF, Popov, VL, Widen, SG, Wood, TG, Vasilakis, N & Tesh, RB 2017, 'Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia', Virology, vol. 501, pp. 166-175. https://doi.org/10.1016/j.virol.2016.11.014

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title = "Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia",

abstract = "The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.",

keywords = "Insect-specific viruses, Orthomyxoviridae, Sinu virus, Thogotovirus genus",

author = "Contreras-Guti{\'e}rrez, \{Mar{\'i}a Ang{\'e}lica\} and Nunes, \{Marcio R.T.\} and Hilda Guzman and Sandra Uribe and \{Gallego G{\'o}mez\}, \{Juan Carlos\} and \{Suaza Vasco\}, \{Juan David\} and Cardoso, \{Jedson F.\} and Popov, \{Vsevolod L.\} and Widen, \{Steven G.\} and Wood, \{Thomas G.\} and Nikos Vasilakis and Tesh, \{Robert B.\}",

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year = "2017",

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doi = "10.1016/j.virol.2016.11.014",

language = "English (US)",

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AU - Contreras-Gutiérrez, María Angélica

AU - Nunes, Marcio R.T.

AU - Guzman, Hilda

AU - Uribe, Sandra

AU - Gallego Gómez, Juan Carlos

AU - Suaza Vasco, Juan David

AU - Cardoso, Jedson F.

AU - Popov, Vsevolod L.

AU - Widen, Steven G.

AU - Wood, Thomas G.

AU - Vasilakis, Nikos

AU - Tesh, Robert B.

PY - 2017/1/15

Y1 - 2017/1/15

N2 - The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

AB - The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.

KW - Insect-specific viruses

KW - Orthomyxoviridae

KW - Sinu virus

KW - Thogotovirus genus

UR - https://www.scopus.com/pages/publications/85002202550

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AN - SCOPUS:85002202550

SN - 0042-6822

VL - 501

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EP - 175

JO - Virology

JF - Virology

ER -

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia

Abstract

Keywords

ASJC Scopus subject areas

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