Size and stability of a naturally occurring virus inhibitor

D. H. Coppenhaver, J. L. Baron, M. L. McKerlie, J. Sabados, S. Baron

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Abstract

We recently described a virus inhibitor (contact-blocking virus inhibitor) which was produced spontaneously by untransformed human and murine cells in tissue culture. This contact-blocking virus inhibitor was characterized by broad antiviral activity, high potency, and reversible inhibition of viral attachment. Unlike interferon, the antiviral activity of the contact-blocking virus inhibitor is not species specific. An inhibitor with similar properties can also be demonstrated in many body fluids and surface secretions. We report here studies on the stability of the antiviral species which indicate that it is resistant to denaturation by heat (100°C), acid (pH 2), and alkali (pH 12). The antiviral activity against all viruses tested resides in a low-molecular-weight molecule. The range of characteristics so far determined for the contact-blocking virus inhibitor distinguishes it from other virus inhibitors reported in the literature.

Original languageEnglish (US)
Pages (from-to)646-649
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume25
Issue number5
StatePublished - 1984

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ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Coppenhaver, D. H., Baron, J. L., McKerlie, M. L., Sabados, J., & Baron, S. (1984). Size and stability of a naturally occurring virus inhibitor. Antimicrobial Agents and Chemotherapy, 25(5), 646-649.