Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury

Tony Chao, David Herndon, Craig Porter, Maria Chondronikola, Anastasia Chaidemenou, Doaa Reda Abdelrahman, Fredrick J. Bohanon, Clark Andersen, Labros S. Sidossis

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, the long-lasting effects of burn injury on skeletal muscle protein turnover are incompletely understood. This study was undertaken to investigate fractional synthesis (FSR) and breakdown (FBR) rates of protein in skeletal muscle of pediatric burn patients (n=42, >30% total body surface area burns) for up to 1 year after injury. Skeletal muscle protein kinetics were measured in the post-prandial state following bolus injections of 13C6 and 15N phenylalanine stable isotopes. Plasma and muscle phenylalanine enrichments were quantified using gas chromatographymass spectrometry.We found that the FSR in burn patients was 2-to 3-fold higher than values from healthy men previously reported in the literature (P≤0.05). The FBR was 4-to 6-fold higher than healthy values (P

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalShock
Volume44
Issue number5
DOIs
StatePublished - 2015

Keywords

  • Metabolism
  • Muscle breakdown
  • Protein turnoverc
  • stable isotopes
  • Thermal injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

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    Chao, T., Herndon, D., Porter, C., Chondronikola, M., Chaidemenou, A., Abdelrahman, D. R., Bohanon, F. J., Andersen, C., & Sidossis, L. S. (2015). Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury. Shock, 44(5), 397-401. https://doi.org/10.1097/SHK.0000000000000454