Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury

Tony Chao, David Herndon, Craig Porter, Maria Chondronikola, Anastasia Chaidemenou, Doaa Reda Abdelrahman, Fredrick J. Bohanon, Clark Andersen, Labros S. Sidossis

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, the long-lasting effects of burn injury on skeletal muscle protein turnover are incompletely understood. This study was undertaken to investigate fractional synthesis (FSR) and breakdown (FBR) rates of protein in skeletal muscle of pediatric burn patients (n=42, >30% total body surface area burns) for up to 1 year after injury. Skeletal muscle protein kinetics were measured in the post-prandial state following bolus injections of 13C6 and 15N phenylalanine stable isotopes. Plasma and muscle phenylalanine enrichments were quantified using gas chromatographymass spectrometry.We found that the FSR in burn patients was 2-to 3-fold higher than values from healthy men previously reported in the literature (P≤0.05). The FBR was 4-to 6-fold higher than healthy values (P

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalShock
Volume44
Issue number5
DOIs
StatePublished - 2015

Fingerprint

Muscle Proteins
Survivors
Skeletal Muscle
Pediatrics
Wounds and Injuries
Phenylalanine
Burns
Body Surface Area
Isotopes
Meals
Spectrum Analysis
Gases
Muscles
Injections
Proteins

Keywords

  • Metabolism
  • Muscle breakdown
  • Protein turnoverc
  • stable isotopes
  • Thermal injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Chao, T., Herndon, D., Porter, C., Chondronikola, M., Chaidemenou, A., Abdelrahman, D. R., ... Sidossis, L. S. (2015). Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury. Shock, 44(5), 397-401. https://doi.org/10.1097/SHK.0000000000000454

Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury. / Chao, Tony; Herndon, David; Porter, Craig; Chondronikola, Maria; Chaidemenou, Anastasia; Abdelrahman, Doaa Reda; Bohanon, Fredrick J.; Andersen, Clark; Sidossis, Labros S.

In: Shock, Vol. 44, No. 5, 2015, p. 397-401.

Research output: Contribution to journalArticle

Chao, T, Herndon, D, Porter, C, Chondronikola, M, Chaidemenou, A, Abdelrahman, DR, Bohanon, FJ, Andersen, C & Sidossis, LS 2015, 'Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury', Shock, vol. 44, no. 5, pp. 397-401. https://doi.org/10.1097/SHK.0000000000000454
Chao T, Herndon D, Porter C, Chondronikola M, Chaidemenou A, Abdelrahman DR et al. Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury. Shock. 2015;44(5):397-401. https://doi.org/10.1097/SHK.0000000000000454
Chao, Tony ; Herndon, David ; Porter, Craig ; Chondronikola, Maria ; Chaidemenou, Anastasia ; Abdelrahman, Doaa Reda ; Bohanon, Fredrick J. ; Andersen, Clark ; Sidossis, Labros S. / Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury. In: Shock. 2015 ; Vol. 44, No. 5. pp. 397-401.
@article{bcae4c00943e473b84b8280a10bb3256,
title = "Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury",
abstract = "Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, the long-lasting effects of burn injury on skeletal muscle protein turnover are incompletely understood. This study was undertaken to investigate fractional synthesis (FSR) and breakdown (FBR) rates of protein in skeletal muscle of pediatric burn patients (n=42, >30{\%} total body surface area burns) for up to 1 year after injury. Skeletal muscle protein kinetics were measured in the post-prandial state following bolus injections of 13C6 and 15N phenylalanine stable isotopes. Plasma and muscle phenylalanine enrichments were quantified using gas chromatographymass spectrometry.We found that the FSR in burn patients was 2-to 3-fold higher than values from healthy men previously reported in the literature (P≤0.05). The FBR was 4-to 6-fold higher than healthy values (P",
keywords = "Metabolism, Muscle breakdown, Protein turnoverc, stable isotopes, Thermal injury",
author = "Tony Chao and David Herndon and Craig Porter and Maria Chondronikola and Anastasia Chaidemenou and Abdelrahman, {Doaa Reda} and Bohanon, {Fredrick J.} and Clark Andersen and Sidossis, {Labros S.}",
year = "2015",
doi = "10.1097/SHK.0000000000000454",
language = "English (US)",
volume = "44",
pages = "397--401",
journal = "Shock",
issn = "1073-2322",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Skeletal muscle protein breakdown remains elevated in pediatric burn survivors up to one-year post-injury

AU - Chao, Tony

AU - Herndon, David

AU - Porter, Craig

AU - Chondronikola, Maria

AU - Chaidemenou, Anastasia

AU - Abdelrahman, Doaa Reda

AU - Bohanon, Fredrick J.

AU - Andersen, Clark

AU - Sidossis, Labros S.

PY - 2015

Y1 - 2015

N2 - Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, the long-lasting effects of burn injury on skeletal muscle protein turnover are incompletely understood. This study was undertaken to investigate fractional synthesis (FSR) and breakdown (FBR) rates of protein in skeletal muscle of pediatric burn patients (n=42, >30% total body surface area burns) for up to 1 year after injury. Skeletal muscle protein kinetics were measured in the post-prandial state following bolus injections of 13C6 and 15N phenylalanine stable isotopes. Plasma and muscle phenylalanine enrichments were quantified using gas chromatographymass spectrometry.We found that the FSR in burn patients was 2-to 3-fold higher than values from healthy men previously reported in the literature (P≤0.05). The FBR was 4-to 6-fold higher than healthy values (P

AB - Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, the long-lasting effects of burn injury on skeletal muscle protein turnover are incompletely understood. This study was undertaken to investigate fractional synthesis (FSR) and breakdown (FBR) rates of protein in skeletal muscle of pediatric burn patients (n=42, >30% total body surface area burns) for up to 1 year after injury. Skeletal muscle protein kinetics were measured in the post-prandial state following bolus injections of 13C6 and 15N phenylalanine stable isotopes. Plasma and muscle phenylalanine enrichments were quantified using gas chromatographymass spectrometry.We found that the FSR in burn patients was 2-to 3-fold higher than values from healthy men previously reported in the literature (P≤0.05). The FBR was 4-to 6-fold higher than healthy values (P

KW - Metabolism

KW - Muscle breakdown

KW - Protein turnoverc

KW - stable isotopes

KW - Thermal injury

UR - http://www.scopus.com/inward/record.url?scp=84945473099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945473099&partnerID=8YFLogxK

U2 - 10.1097/SHK.0000000000000454

DO - 10.1097/SHK.0000000000000454

M3 - Article

C2 - 26263438

AN - SCOPUS:84945473099

VL - 44

SP - 397

EP - 401

JO - Shock

JF - Shock

SN - 1073-2322

IS - 5

ER -