Skeletal scintigraphy with technetium-99m-tetraphenyl porphyrin sulfonate for the detection and determination of osteomyelitis in an animal model

S. A. Ali, F. Cesani, M. L. Nusynowitz, E. G. Briscoe, M. E. Shirtliff, J. T. Mader

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This article explores the accumulation of 99mTc-tetraphenyl porphyrin sulfonate (TPPS4) at inflammatory sites, especially osteomyelitis, and compares the results with 111In Cl3 and 111In-WBC in an animal model. Methods: Osteomyelitis was induced in 12 New Zealand white rabbits by injecting staphylococcus aureus in the left tibia. Three weeks later, radiographs confirmed the disease. Two hours later, after injection of 74 MBq 99mTc-TPPS4, scintiphotos of the lower extremities were acquired and repeat scintiphotos were obtained 24 hr after injection of 5.55 MBq 111In Cl3. After these studies, 24- and 48-hr scintiphotos of the lower extremities were acquired after injecting 5.55 MBq 111In-labeled WBC. Results: The left tibia averaged three times the uptake with 99mTc-TPPS4 compared with right tibia; with 111In Cl3 and 111In WBC the ratios are two times. These three radiopharmaceuticals reveal positive images, but the image quality using 99mTc-TPPS4 is better, as would be expected from the more favorable physical characteristics of 99mTc and the higher uptake. Conclusion: The traditional combination of three-phase bone and 67Ga- citrate scintigraphy can be replaced by a single injection of 99mTc- TPPS4 with imaging as early as 2 hr. Finally, the use 99mTc-TPPS4 should result in a substantial reduction in radiopharmaceutical cost.

Original languageEnglish (US)
Pages (from-to)1999-2002
Number of pages4
JournalJournal of Nuclear Medicine
Volume38
Issue number12
StatePublished - Dec 1997

Fingerprint

Technetium
Porphyrins
Osteomyelitis
Radionuclide Imaging
Animal Models
Tibia
Radiopharmaceuticals
Injections
Lower Extremity
Citric Acid
Staphylococcus aureus
5,10,15,20-tetrakis(4-sulphophenyl)-porphine dodecahydrate
Rabbits
Costs and Cost Analysis
Bone and Bones

Keywords

  • Indium- 111
  • Osteomyelitis
  • Technetium-99m-tetraphenyl porphyrin sulfonate
  • White blood cells

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Ali, S. A., Cesani, F., Nusynowitz, M. L., Briscoe, E. G., Shirtliff, M. E., & Mader, J. T. (1997). Skeletal scintigraphy with technetium-99m-tetraphenyl porphyrin sulfonate for the detection and determination of osteomyelitis in an animal model. Journal of Nuclear Medicine, 38(12), 1999-2002.

Skeletal scintigraphy with technetium-99m-tetraphenyl porphyrin sulfonate for the detection and determination of osteomyelitis in an animal model. / Ali, S. A.; Cesani, F.; Nusynowitz, M. L.; Briscoe, E. G.; Shirtliff, M. E.; Mader, J. T.

In: Journal of Nuclear Medicine, Vol. 38, No. 12, 12.1997, p. 1999-2002.

Research output: Contribution to journalArticle

Ali, SA, Cesani, F, Nusynowitz, ML, Briscoe, EG, Shirtliff, ME & Mader, JT 1997, 'Skeletal scintigraphy with technetium-99m-tetraphenyl porphyrin sulfonate for the detection and determination of osteomyelitis in an animal model', Journal of Nuclear Medicine, vol. 38, no. 12, pp. 1999-2002.
Ali, S. A. ; Cesani, F. ; Nusynowitz, M. L. ; Briscoe, E. G. ; Shirtliff, M. E. ; Mader, J. T. / Skeletal scintigraphy with technetium-99m-tetraphenyl porphyrin sulfonate for the detection and determination of osteomyelitis in an animal model. In: Journal of Nuclear Medicine. 1997 ; Vol. 38, No. 12. pp. 1999-2002.
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abstract = "This article explores the accumulation of 99mTc-tetraphenyl porphyrin sulfonate (TPPS4) at inflammatory sites, especially osteomyelitis, and compares the results with 111In Cl3 and 111In-WBC in an animal model. Methods: Osteomyelitis was induced in 12 New Zealand white rabbits by injecting staphylococcus aureus in the left tibia. Three weeks later, radiographs confirmed the disease. Two hours later, after injection of 74 MBq 99mTc-TPPS4, scintiphotos of the lower extremities were acquired and repeat scintiphotos were obtained 24 hr after injection of 5.55 MBq 111In Cl3. After these studies, 24- and 48-hr scintiphotos of the lower extremities were acquired after injecting 5.55 MBq 111In-labeled WBC. Results: The left tibia averaged three times the uptake with 99mTc-TPPS4 compared with right tibia; with 111In Cl3 and 111In WBC the ratios are two times. These three radiopharmaceuticals reveal positive images, but the image quality using 99mTc-TPPS4 is better, as would be expected from the more favorable physical characteristics of 99mTc and the higher uptake. Conclusion: The traditional combination of three-phase bone and 67Ga- citrate scintigraphy can be replaced by a single injection of 99mTc- TPPS4 with imaging as early as 2 hr. Finally, the use 99mTc-TPPS4 should result in a substantial reduction in radiopharmaceutical cost.",
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