Sleep characteristics and inflammatory biomarkers among midlife women

Sara Nowakowski, Karen A. Matthews, Roland Von Känel, Martica H. Hall, Rebecca C. Thurston

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Study Objectives: Research suggests that sleep disturbances are associated with elevated levels of inflammation. Some evidence indicates that women may be particularly vulnerable; increased levels of inflammatory biomarkers with sleep disturbances are primarily observed among women. Midlife, which encompasses the menopause transition, is typically reported as a time of poor sleep. We tested whether poorer objectively measured sleep characteristics were related to a poorer inflammatory profile in midlife women. Methods: Two hundred ninety-five peri- and postmenopausal women aged 40-60 completed 3 days of wrist actigraphy, physiologic hot flash monitoring, questionnaires (e.g. Berlin sleep apnea risk questionnaire], and a blood draw for the assessment of inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), and von Willebrand factor (VWF) antigen. Associations of objective (actigraphy) sleep with inflammatory markers were tested in regression models. Sleep efficiency was inverse log transformed. Covariates included age, race/ ethnicity, education, body mass index, sleep apnea risk, homeostatic model assessment (a measure of insulin resistance), systolic blood pressure, low-density lipoprotein cholesterol, and physical activity. Results: In separate models controlling for age, race/ethnicity, and education, lower sleep efficiency was associated with higher IL-6 [b(SE) = .02 (.10), p = .003] and VWF [b(SE) = .02 (.08), p = .002]. More minutes awake after sleep onset was associated with higher VWF [b(SE) = .12 (.06), p = .01]. Findings persisted in multivariable models. Conclusions: Lower sleep efficiency and more minutes awake after sleep onset were independently associated with higher circulating levels of VWF. Lower sleep efficiency was associated with higher circulating levels of IL-6. These findings suggest that sleep disturbances are associated with greater circulating inflammation in midlife women.

Original languageEnglish (US)
Article number049
JournalSleep
Volume41
Issue number5
DOIs
StatePublished - May 1 2018

Fingerprint

Sleep
Biomarkers
von Willebrand Factor
Actigraphy
Interleukin-6
Sleep Apnea Syndromes
Hot Flashes
Blood Pressure
Inflammation
Education
Berlin
Menopause
Wrist
C-Reactive Protein
LDL Cholesterol
Insulin Resistance
Body Mass Index
Exercise

Keywords

  • actigraphy
  • inflammation
  • menopause
  • sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

Cite this

Nowakowski, S., Matthews, K. A., Von Känel, R., Hall, M. H., & Thurston, R. C. (2018). Sleep characteristics and inflammatory biomarkers among midlife women. Sleep, 41(5), [049]. https://doi.org/10.1093/sleep/zsy049

Sleep characteristics and inflammatory biomarkers among midlife women. / Nowakowski, Sara; Matthews, Karen A.; Von Känel, Roland; Hall, Martica H.; Thurston, Rebecca C.

In: Sleep, Vol. 41, No. 5, 049, 01.05.2018.

Research output: Contribution to journalArticle

Nowakowski, S, Matthews, KA, Von Känel, R, Hall, MH & Thurston, RC 2018, 'Sleep characteristics and inflammatory biomarkers among midlife women', Sleep, vol. 41, no. 5, 049. https://doi.org/10.1093/sleep/zsy049
Nowakowski S, Matthews KA, Von Känel R, Hall MH, Thurston RC. Sleep characteristics and inflammatory biomarkers among midlife women. Sleep. 2018 May 1;41(5). 049. https://doi.org/10.1093/sleep/zsy049
Nowakowski, Sara ; Matthews, Karen A. ; Von Känel, Roland ; Hall, Martica H. ; Thurston, Rebecca C. / Sleep characteristics and inflammatory biomarkers among midlife women. In: Sleep. 2018 ; Vol. 41, No. 5.
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