Small animal models of filovirus disease: recent advances and future directions

Robert Cross, Karla A. Fenton, Thomas Geisbert

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Introduction: Small animal models have played a critical role in understanding the pathogenesis and transmission of disease caused by filoviruses. Notably, small animals have served to identify and validate many different approaches to countering infection with these highly pathogenic viruses. Nonetheless, predictive efficacy between each model does not appear to be equivalent as higher order animals seem to be more prognostic and therefore successful in the evaluation of medical countermeasures (MCM). Areas covered: This review comprehensively details the available small animal models of filovirus infection and discusses the benefits and shortcomings of each model with respect to the development of MCM. An up-to-date evaluation of mouse, hamster, guinea pig, and ferret models is provided. Expert opinion: The recent development of the domestic ferret model for ebolavirus offers a small animal model that faithfully reproduces most features of human disease without the need for viral adaptation or an immunocompromised host. That being said, choosing a small animal model to evaluate a particular MCM must consider potential confounders associated with each model. These confounding issues include incomplete host immune systems or mutations in the challenge virus that enables the disease.

Original languageEnglish (US)
Pages (from-to)1027-1040
Number of pages14
JournalExpert Opinion on Drug Discovery
Volume13
Issue number11
DOIs
StatePublished - Nov 2 2018

Fingerprint

Animal Disease Models
Animal Models
Ferrets
Ebolavirus
Expert Testimony
Immunocompromised Host
Virus Diseases
Infection
Cricetinae
Immune System
Guinea Pigs
Viruses
Mutation
Direction compound

Keywords

  • animal models
  • drugs
  • Ebola
  • ferrets
  • filovirus
  • guinea pigs
  • hamsters
  • Marburg
  • medical countermeasures
  • mice
  • nonhuman primates
  • rodents
  • therapeutics
  • vaccines

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Small animal models of filovirus disease : recent advances and future directions. / Cross, Robert; Fenton, Karla A.; Geisbert, Thomas.

In: Expert Opinion on Drug Discovery, Vol. 13, No. 11, 02.11.2018, p. 1027-1040.

Research output: Contribution to journalReview article

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