Small-cell carcinoma of the lung

the prognostic significance of stage on survival

Judith A. Cooksey, Jacob D. Bitran, Richard K. Desser, Ann E. Kinnealey, Uri Mintz, Martin Colman, George Cimochowski, Melvin L. Griem, Tom R. Demeester, Harvey M. Golomb

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalEuropean Journal of Cancer (1965)
Volume15
Issue number6
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Small Cell Lung Carcinoma
Survival
Small Cell Carcinoma
Thorax
Recurrence
Combined Modality Therapy
Leucovorin
Methotrexate
Doxorubicin
Cyclophosphamide
Radiotherapy
Neoplasm Metastasis
Lung
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Cooksey, J. A., Bitran, J. D., Desser, R. K., Kinnealey, A. E., Mintz, U., Colman, M., ... Golomb, H. M. (1979). Small-cell carcinoma of the lung: the prognostic significance of stage on survival. European Journal of Cancer (1965), 15(6), 859-865. https://doi.org/10.1016/0014-2964(79)90227-5

Small-cell carcinoma of the lung : the prognostic significance of stage on survival. / Cooksey, Judith A.; Bitran, Jacob D.; Desser, Richard K.; Kinnealey, Ann E.; Mintz, Uri; Colman, Martin; Cimochowski, George; Griem, Melvin L.; Demeester, Tom R.; Golomb, Harvey M.

In: European Journal of Cancer (1965), Vol. 15, No. 6, 1979, p. 859-865.

Research output: Contribution to journalArticle

Cooksey, JA, Bitran, JD, Desser, RK, Kinnealey, AE, Mintz, U, Colman, M, Cimochowski, G, Griem, ML, Demeester, TR & Golomb, HM 1979, 'Small-cell carcinoma of the lung: the prognostic significance of stage on survival', European Journal of Cancer (1965), vol. 15, no. 6, pp. 859-865. https://doi.org/10.1016/0014-2964(79)90227-5
Cooksey, Judith A. ; Bitran, Jacob D. ; Desser, Richard K. ; Kinnealey, Ann E. ; Mintz, Uri ; Colman, Martin ; Cimochowski, George ; Griem, Melvin L. ; Demeester, Tom R. ; Golomb, Harvey M. / Small-cell carcinoma of the lung : the prognostic significance of stage on survival. In: European Journal of Cancer (1965). 1979 ; Vol. 15, No. 6. pp. 859-865.
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