Small-cell carcinoma of the lung: the prognostic significance of stage on survival

Judith A. Cooksey; Jacob D. Bitran; Richard K. Desser; Ann E. Kinnealey; Uri Mintz; Martin Colman; George Cimochowski; Melvin L. Griem; Tom R. Demeester; Harvey M. Golomb

doi:10.1016/0014-2964(79)90227-5

Small-cell carcinoma of the lung: the prognostic significance of stage on survival

Judith A. Cooksey, Jacob D. Bitran, Richard K. Desser, Ann E. Kinnealey, Uri Mintz, Martin Colman, George Cimochowski, Melvin L. Griem, Tom R. Demeester, Harvey M. Golomb

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.

Original language	English (US)
Pages (from-to)	859-865
Number of pages	7
Journal	European Journal of Cancer (1965)
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/0014-2964(79)90227-5
State	Published - Jun 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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@article{5332c31b6aff4127958756e77a3f2858,

title = "Small-cell carcinoma of the lung: the prognostic significance of stage on survival",

abstract = "Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.",

author = "Cooksey, {Judith A.} and Bitran, {Jacob D.} and Desser, {Richard K.} and Kinnealey, {Ann E.} and Uri Mintz and Martin Colman and George Cimochowski and Griem, {Melvin L.} and Demeester, {Tom R.} and Golomb, {Harvey M.}",

note = "Funding Information: Department of Energy under Contract EY-76-C-02-0069. Address for reprints to: Dr. J. Bitran, Section of Hematology/Oncology, Michael Reese Hospital and Medical Center, 29th Street & Ellis Avenue, Chicago, Illinois 60616",

year = "1979",

month = jun,

doi = "10.1016/0014-2964(79)90227-5",

language = "English (US)",

volume = "15",

pages = "859--865",

journal = "European Journal of Cancer (1965)",

issn = "0014-2964",

publisher = "Pergamon Press Ltd.",

number = "6",

}

TY - JOUR

T1 - Small-cell carcinoma of the lung

T2 - the prognostic significance of stage on survival

AU - Cooksey, Judith A.

AU - Bitran, Jacob D.

AU - Desser, Richard K.

AU - Kinnealey, Ann E.

AU - Mintz, Uri

AU - Colman, Martin

AU - Cimochowski, George

AU - Griem, Melvin L.

AU - Demeester, Tom R.

AU - Golomb, Harvey M.

N1 - Funding Information: Department of Energy under Contract EY-76-C-02-0069. Address for reprints to: Dr. J. Bitran, Section of Hematology/Oncology, Michael Reese Hospital and Medical Center, 29th Street & Ellis Avenue, Chicago, Illinois 60616

PY - 1979/6

Y1 - 1979/6

N2 - Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.

AB - Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.

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JO - European Journal of Cancer (1965)

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IS - 6

ER -

Small-cell carcinoma of the lung: the prognostic significance of stage on survival

Abstract

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