Small-cell carcinoma of the lung: the prognostic significance of stage on survival

Judith A. Cooksey; Jacob D. Bitran; Richard K. Desser; Ann E. Kinnealey; Uri Mintz; Martin Colman; George Cimochowski; Melvin L. Griem; Tom R. Demeester; Harvey M. Golomb

doi:10.1016/0014-2964(79)90227-5

Small-cell carcinoma of the lung: the prognostic significance of stage on survival

Judith A. Cooksey
, Jacob D. Bitran
, Richard K. Desser
, Ann E. Kinnealey
, Uri Mintz
, Martin Colman
, George Cimochowski
, Melvin L. Griem
, Tom R. Demeester
, Harvey M. Golomb

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.

Original language	English (US)
Pages (from-to)	859-865
Number of pages	7
Journal	European Journal of Cancer (1965)
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/0014-2964(79)90227-5
State	Published - Jun 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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@article{5332c31b6aff4127958756e77a3f2858,

title = "Small-cell carcinoma of the lung: the prognostic significance of stage on survival",

abstract = "Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.",

author = "Cooksey, \{Judith A.\} and Bitran, \{Jacob D.\} and Desser, \{Richard K.\} and Kinnealey, \{Ann E.\} and Uri Mintz and Martin Colman and George Cimochowski and Griem, \{Melvin L.\} and Demeester, \{Tom R.\} and Golomb, \{Harvey M.\}",

note = "Funding Information: Department of Energy under Contract EY-76-C-02-0069. Address for reprints to: Dr. J. Bitran, Section of Hematology/Oncology, Michael Reese Hospital and Medical Center, 29th Street \& Ellis Avenue, Chicago, Illinois 60616",

year = "1979",

month = jun,

doi = "10.1016/0014-2964(79)90227-5",

language = "English (US)",

volume = "15",

pages = "859--865",

journal = "European Journal of Cancer (1965)",

issn = "0014-2964",

publisher = "Pergamon Press Ltd.",

number = "6",

}

TY - JOUR

T1 - Small-cell carcinoma of the lung

T2 - the prognostic significance of stage on survival

AU - Cooksey, Judith A.

AU - Bitran, Jacob D.

AU - Desser, Richard K.

AU - Kinnealey, Ann E.

AU - Mintz, Uri

AU - Colman, Martin

AU - Cimochowski, George

AU - Griem, Melvin L.

AU - Demeester, Tom R.

AU - Golomb, Harvey M.

N1 - Funding Information: Department of Energy under Contract EY-76-C-02-0069. Address for reprints to: Dr. J. Bitran, Section of Hematology/Oncology, Michael Reese Hospital and Medical Center, 29th Street & Ellis Avenue, Chicago, Illinois 60616

PY - 1979/6

Y1 - 1979/6

N2 - Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.

AB - Thirty-three patients (pts) with small cell carcinoma (SCC) were treated with combined modality therapy consisting of radiation therapy (300 rad/15 fractions) and cyclophosphamide, adriamycin, methotrexate and leucovorin (CAML). Thirty of 33 pts showed an objective response to therapy with a median survival of 11.6 months for all patients. When survival was determined by stage, pts with disease limited to the chest had a better median survival (18.9 months) than pts with metastases to supraclavicular nodes (11.6 months, median) or wide-spread metastatic disease (8.0 months, median). Not withstanding the routine use of chest irradiation, lung recurrences developed in 7/33 pts and were more frequent than CNS relapse, 4/33. If survival is to be increased in SCC, more aggressive means of local tumor control need to be pursued.

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UR - https://www.scopus.com/pages/publications/0018746216#tab=citedBy

U2 - 10.1016/0014-2964(79)90227-5

DO - 10.1016/0014-2964(79)90227-5

M3 - Article

C2 - 499274

AN - SCOPUS:0018746216

SN - 0014-2964

VL - 15

SP - 859

EP - 865

JO - European Journal of Cancer (1965)

JF - European Journal of Cancer (1965)

IS - 6

ER -

Small-cell carcinoma of the lung: the prognostic significance of stage on survival

Abstract

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