Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage

Keyphrases

• Induced Apoptosis 100%
• DNA Damage 100%
• Cancer Cells 100%
• Small Molecules 100%
• Selective Inhibitor 100%
• Chemical Probes 100%
• Mono-ADP-ribosylation 100%
• Mono-ADP-ribosyltransferase 100%
• PARP10 100%
• Immune Response 50%
• DNA Repair 50%
• Biological Activity 50%
• Study Support 50%
• Cell Proliferation 50%
• Biological Processes 50%
• Poly(ADP-ribose) 50%
• ADP-ribosyltransferase 50%
• Cell Biology 50%
• DNA Damage Repair 50%
• HeLa Cells 50%
• Cellular Signaling 50%
• Genotoxic Stress 50%
• Selectivity Profile 50%
• Biological Relevance 50%
• Potent Inhibitor 50%
• Induced Cell Death 50%
• Selective Inhibition 50%
• PARP Family 50%
• Hydroxyurea 50%
• Family Play 50%
• Disease Relevance 50%
• Profile Model 50%
• Diphtheria Toxin 50%
• Tool Compound 50%

Biochemistry, Genetics and Molecular Biology

• DNA Repair 100%
• Cancer Cell 100%
• DNA Damage 100%
• Small Molecule 100%
• Adenosine Diphosphate 100%
• Mono Adenosine Diphosphate Ribosylation 100%
• ADP-ribosylation 50%
• Cell Proliferation 50%
• Enzyme 50%
• Biological Activity 50%
• Signal Transduction 50%
• Cell Death 50%
• Biological Phenomena and Functions Concerning the Entire Organism 50%
• Immune Response 50%
• Poly ADP Ribose Polymerase 50%
• Hydroxycarbamide 50%
• Diphtheria Toxin 50%