Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin

George Kramer, C. E. Wade, M. R E Silva

Research output: Contribution to journalArticle

Abstract

The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994

Fingerprint

Resuscitation
Hypovolemia
Hemoglobin
Cardiac Output
Hemoglobins
Cardiac Volume
Hemorrhagic Shock
Hematocrit
Hemorrhage
Oxygen
Wounds and Injuries
Therapeutics
crystalloid solutions

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin. / Kramer, George; Wade, C. E.; Silva, M. R E.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 5, 11.1994.

Research output: Contribution to journalArticle

@article{414fc30a016148c892e35f732e7eb457,
title = "Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin",
abstract = "The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.",
author = "George Kramer and Wade, {C. E.} and Silva, {M. R E}",
year = "1994",
month = "11",
language = "English (US)",
volume = "22",
journal = "Artificial Cells, Nanomedicine and Biotechnology",
issn = "2169-1401",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin

AU - Kramer, George

AU - Wade, C. E.

AU - Silva, M. R E

PY - 1994/11

Y1 - 1994/11

N2 - The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.

AB - The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.

UR - http://www.scopus.com/inward/record.url?scp=0028533466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028533466&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028533466

VL - 22

JO - Artificial Cells, Nanomedicine and Biotechnology

JF - Artificial Cells, Nanomedicine and Biotechnology

SN - 2169-1401

IS - 5

ER -