Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin

G. C. Kramer; C. E. Wade; M. R.E. Silva

Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin

G. C. Kramer, C. E. Wade, M. R.E. Silva

Anesthesiology

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.

Original language	English (US)
Pages (from-to)	A119
Journal	Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume	22
Issue number	5
State	Published - Nov 1994
Event	Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA Duration: Jul 24 1994 → Jul 27 1994

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering

Cite this

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title = "Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin",

abstract = "The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.",

author = "Kramer, {G. C.} and Wade, {C. E.} and Silva, {M. R.E.}",

year = "1994",

month = nov,

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AU - Kramer, G. C.

AU - Wade, C. E.

AU - Silva, M. R.E.

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N2 - The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.

AB - The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.

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M3 - Conference article

AN - SCOPUS:0028533466

SN - 1073-1199

VL - 22

SP - A119

JO - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

JF - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

IS - 5

T2 - Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI)

Y2 - 24 July 1994 through 27 July 1994

ER -

Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin

Abstract

ASJC Scopus subject areas

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