The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|State||Published - Nov 1994|
ASJC Scopus subject areas
- Biomedical Engineering