Smoke inhalation causes a delayed increase in airway blood flow to primarily uninjured lung areas

H. M. Loick, L. D. Traber, J. C. Stothert, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Single lung inhalation injury causes tissue damage to the contralateral lung. We therefore examined airway blood flow after smoke inhalation in chronic instrumented sheep to get further information about the underlying pathophysiology. Design/patients: The right lung and lower trachea of 5 animals were smoke-exposed, while their left lung was air-insufflated using a split ventilation technique. Three animals, where both lungs were only air-insufflated, served as controls. Blood flow to the airway was measured using a labeled microsphere technique. All animals were studied for 24 h following smoke inhalation. Then they were sacrificed and their tissues harvested. Results: The airway blood flow to the smoke-exposed lung was elevated 11-fold immediately after inhalation injury. The bronchial blood flow to the air insufflated lung became significantly elevated 24 h post-smoke, although to a lesser extent. The control animals did not show any changes of bronchial blood flow during the observation time. Conclusions: Damage to one lung can lead to pathophysiologic changes in the contralateral lung. This response appears to be mediated by hematogenous factors.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalIntensive Care Medicine
Volume21
Issue number4
DOIs
StatePublished - Apr 1995

Fingerprint

Smoke
Inhalation
Lung
Air
Patient Rights
Lung Injury
Trachea
Microspheres
Ventilation
Sheep
Observation
Wounds and Injuries

Keywords

  • Bronchi (blood supply)
  • Microspheres
  • Smoke inhalation injury
  • Splanchnic circulation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Loick, H. M., Traber, L. D., Stothert, J. C., Herndon, D., & Traber, D. L. (1995). Smoke inhalation causes a delayed increase in airway blood flow to primarily uninjured lung areas. Intensive Care Medicine, 21(4), 326-333. https://doi.org/10.1007/BF01705411

Smoke inhalation causes a delayed increase in airway blood flow to primarily uninjured lung areas. / Loick, H. M.; Traber, L. D.; Stothert, J. C.; Herndon, David; Traber, D. L.

In: Intensive Care Medicine, Vol. 21, No. 4, 04.1995, p. 326-333.

Research output: Contribution to journalArticle

Loick, H. M. ; Traber, L. D. ; Stothert, J. C. ; Herndon, David ; Traber, D. L. / Smoke inhalation causes a delayed increase in airway blood flow to primarily uninjured lung areas. In: Intensive Care Medicine. 1995 ; Vol. 21, No. 4. pp. 326-333.
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