Soluble CD30 concentrations in ESRD patients with and without panel reactive HLA antibodies

Smita Vaidya, David Partlow, Titus Barnes, Phillip Thomas, Kristin Gugliuzza

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: In this retrospective study we compared accuracy of panel reactive antibodies (PRA) with serum soluble CD30 (sCD30) contents in predicting acute rejection crisis post-renal transplant. Methods: Pre-transplant sera from 115 patients were evaluated for their PRA and sCD30 concentrations. All patients received calcineurin inhibitorbased immunosuppressive therapy. Objective measurements for rejection were biopsy-proven acute rejection (AR) episodes within first six months of the transplant. Post-transplant sera of patients with AR were tested for the presence of donor-specific HLA antibodies (DSA). Results: Overall AR rate was 16% (18/115). Patients positive for PRA and sCD30 tests were at significantly higher risk for AVR compared with those patients negative for both the tests (36% vs. 5%, p = 0.01). Among negative PRA patients risk for AR was significantly elevated if they were also tested positive for sCD30 concentrations (21% vs. 5%, p = 0.04). Of the 18 patients with AR, 14 were positive for sCD30, and 13 of them (93%) developed DSA post-transplant (p = 0.001). Conclusion: These data showed that patients positive for sCD30 contents are at high risk for the development of DSA and AR post-transplant regardless of their pre-transplant PRA.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalClinical Transplantation
Volume20
Issue number4
DOIs
StatePublished - Jul 1 2006

Keywords

  • Acute rejection
  • Panel reactive antibodies
  • Renal transplantation
  • sCD30

ASJC Scopus subject areas

  • Transplantation

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