Soluble guanylyl cyclase

More secrets revealed

Anastasia Pyriochou, Andreas Papapetropoulos

Research output: Contribution to journalReview article

92 Citations (Scopus)

Abstract

Guanylyl cyclases (GCs) are enzymes that convert guanosine-5′- triphosphate (GTP) to cyclic guanosine-3′,5′-monophosphate (cGMP). The second messenger cGMP participates in signaling by (1) stimulating the activity of kinases that belong to the protein kinase G family, (2) altering the conductance of cGMP-gated ion channels and (3) changing the activity of cGMP-regulated phosphodiesterases. In contrast to adenylyl cyclases which exist as membrane-bound molecules, guanylyl cyclases (GC) occur in both membrane-bound and cytosolic forms. The particulate GC (pGC) isoforms serve as receptors for natriuretic peptides, while soluble GC (sGC) is the "receptor" for nitric oxide (NO). In addition to the difference in ligands and subcellular organization, the two forms of GC also differ in that pGC exists in homodimeric form, while typically sGC occurs as a heterodimer. Herein, we will review the literature on sGC subunit structure and discuss the regulation of the enzyme at the transcriptional and post-translational level.

Original languageEnglish (US)
Pages (from-to)407-413
Number of pages7
JournalCellular Signalling
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

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Guanosine Monophosphate
Guanylate Cyclase
Guanylate Cyclase-Coupled Receptors
Cyclic GMP-Dependent Protein Kinases
Natriuretic Peptides
Membranes
Phosphoric Diester Hydrolases
Second Messenger Systems
Enzymes
Guanosine Triphosphate
Ion Channels
Adenylyl Cyclases
Nitric Oxide
Protein Isoforms
Phosphotransferases
Ligands
Soluble Guanylyl Cyclase

Keywords

  • cGMP
  • Guanylyl cyclase
  • Nitric oxide

ASJC Scopus subject areas

  • Cell Biology

Cite this

Soluble guanylyl cyclase : More secrets revealed. / Pyriochou, Anastasia; Papapetropoulos, Andreas.

In: Cellular Signalling, Vol. 17, No. 4, 01.04.2005, p. 407-413.

Research output: Contribution to journalReview article

Pyriochou, Anastasia ; Papapetropoulos, Andreas. / Soluble guanylyl cyclase : More secrets revealed. In: Cellular Signalling. 2005 ; Vol. 17, No. 4. pp. 407-413.
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