TY - JOUR
T1 - Soluble guanylyl cyclase
T2 - More secrets revealed
AU - Pyriochou, Anastasia
AU - Papapetropoulos, Andreas
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2005/4
Y1 - 2005/4
N2 - Guanylyl cyclases (GCs) are enzymes that convert guanosine-5′- triphosphate (GTP) to cyclic guanosine-3′,5′-monophosphate (cGMP). The second messenger cGMP participates in signaling by (1) stimulating the activity of kinases that belong to the protein kinase G family, (2) altering the conductance of cGMP-gated ion channels and (3) changing the activity of cGMP-regulated phosphodiesterases. In contrast to adenylyl cyclases which exist as membrane-bound molecules, guanylyl cyclases (GC) occur in both membrane-bound and cytosolic forms. The particulate GC (pGC) isoforms serve as receptors for natriuretic peptides, while soluble GC (sGC) is the "receptor" for nitric oxide (NO). In addition to the difference in ligands and subcellular organization, the two forms of GC also differ in that pGC exists in homodimeric form, while typically sGC occurs as a heterodimer. Herein, we will review the literature on sGC subunit structure and discuss the regulation of the enzyme at the transcriptional and post-translational level.
AB - Guanylyl cyclases (GCs) are enzymes that convert guanosine-5′- triphosphate (GTP) to cyclic guanosine-3′,5′-monophosphate (cGMP). The second messenger cGMP participates in signaling by (1) stimulating the activity of kinases that belong to the protein kinase G family, (2) altering the conductance of cGMP-gated ion channels and (3) changing the activity of cGMP-regulated phosphodiesterases. In contrast to adenylyl cyclases which exist as membrane-bound molecules, guanylyl cyclases (GC) occur in both membrane-bound and cytosolic forms. The particulate GC (pGC) isoforms serve as receptors for natriuretic peptides, while soluble GC (sGC) is the "receptor" for nitric oxide (NO). In addition to the difference in ligands and subcellular organization, the two forms of GC also differ in that pGC exists in homodimeric form, while typically sGC occurs as a heterodimer. Herein, we will review the literature on sGC subunit structure and discuss the regulation of the enzyme at the transcriptional and post-translational level.
KW - Guanylyl cyclase
KW - Nitric oxide
KW - cGMP
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U2 - 10.1016/j.cellsig.2004.09.008
DO - 10.1016/j.cellsig.2004.09.008
M3 - Review article
C2 - 15601619
AN - SCOPUS:10444235057
SN - 0898-6568
VL - 17
SP - 407
EP - 413
JO - Cellular Signalling
JF - Cellular Signalling
IS - 4
ER -