Somatic cell hybrid assignment of a structural gene for human β glucuronidase to chromosome 7 by use of an X/7 translocation

T. S. Chan, M. P. Reardon, R. M. Greenstein

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Conflicting results have been reported with regard to the human chromosomal localization of the structural gene for β glucuronidase (βGUS). Recently, the authors have established a human fibroblast strain with a balanced reciprocal X/7 translocation, 46,XX,t(X,7)(Xqter→ Xq21::7p22→7qter)(Xpter→Xq21::7p22→7pter)(Sauer et al., 1977). This strain has given the authors a unique opportunity to resolve the above controversy. The present communication describes the results obtained by using human mouse hybrids prepared from this fibroblast strain, which clearly indicate that human βGUS is localized on chromosome 7.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalCytogenetics and Cell Genetics
Volume17
Issue number5
StatePublished - 1976
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 7
Hybrid Cells
Glucuronidase
Genes
Fibroblasts

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Somatic cell hybrid assignment of a structural gene for human β glucuronidase to chromosome 7 by use of an X/7 translocation. / Chan, T. S.; Reardon, M. P.; Greenstein, R. M.

In: Cytogenetics and Cell Genetics, Vol. 17, No. 5, 1976, p. 291-295.

Research output: Contribution to journalArticle

@article{c95cea53f67b4f1f8c9562a7b5dc3aeb,
title = "Somatic cell hybrid assignment of a structural gene for human β glucuronidase to chromosome 7 by use of an X/7 translocation",
abstract = "Conflicting results have been reported with regard to the human chromosomal localization of the structural gene for β glucuronidase (βGUS). Recently, the authors have established a human fibroblast strain with a balanced reciprocal X/7 translocation, 46,XX,t(X,7)(Xqter→ Xq21::7p22→7qter)(Xpter→Xq21::7p22→7pter)(Sauer et al., 1977). This strain has given the authors a unique opportunity to resolve the above controversy. The present communication describes the results obtained by using human mouse hybrids prepared from this fibroblast strain, which clearly indicate that human βGUS is localized on chromosome 7.",
author = "Chan, {T. S.} and Reardon, {M. P.} and Greenstein, {R. M.}",
year = "1976",
language = "English (US)",
volume = "17",
pages = "291--295",
journal = "Cytogenetic and Genome Research",
issn = "1424-8581",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Somatic cell hybrid assignment of a structural gene for human β glucuronidase to chromosome 7 by use of an X/7 translocation

AU - Chan, T. S.

AU - Reardon, M. P.

AU - Greenstein, R. M.

PY - 1976

Y1 - 1976

N2 - Conflicting results have been reported with regard to the human chromosomal localization of the structural gene for β glucuronidase (βGUS). Recently, the authors have established a human fibroblast strain with a balanced reciprocal X/7 translocation, 46,XX,t(X,7)(Xqter→ Xq21::7p22→7qter)(Xpter→Xq21::7p22→7pter)(Sauer et al., 1977). This strain has given the authors a unique opportunity to resolve the above controversy. The present communication describes the results obtained by using human mouse hybrids prepared from this fibroblast strain, which clearly indicate that human βGUS is localized on chromosome 7.

AB - Conflicting results have been reported with regard to the human chromosomal localization of the structural gene for β glucuronidase (βGUS). Recently, the authors have established a human fibroblast strain with a balanced reciprocal X/7 translocation, 46,XX,t(X,7)(Xqter→ Xq21::7p22→7qter)(Xpter→Xq21::7p22→7pter)(Sauer et al., 1977). This strain has given the authors a unique opportunity to resolve the above controversy. The present communication describes the results obtained by using human mouse hybrids prepared from this fibroblast strain, which clearly indicate that human βGUS is localized on chromosome 7.

UR - http://www.scopus.com/inward/record.url?scp=0017042443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017042443&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 291

EP - 295

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

SN - 1424-8581

IS - 5

ER -