Conflicting results have been reported with regard to the human chromosomal localization of the structural gene for β glucuronidase (βGUS). Recently, the authors have established a human fibroblast strain with a balanced reciprocal X/7 translocation, 46,XX,t(X,7)(Xqter→ Xq21::7p22→7qter)(Xpter→Xq21::7p22→7pter)(Sauer et al., 1977). This strain has given the authors a unique opportunity to resolve the above controversy. The present communication describes the results obtained by using human mouse hybrids prepared from this fibroblast strain, which clearly indicate that human βGUS is localized on chromosome 7.
|Original language||English (US)|
|Number of pages||5|
|Journal||Cytogenetics and Cell Genetics|
|State||Published - 1976|
ASJC Scopus subject areas
- Cell Biology