Somatic cell hybrid assignment of a structural gene for human β glucuronidase to chromosome 7 by use of an X/7 translocation

T. S. Chan, M. P. Reardon, R. M. Greenstein

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Conflicting results have been reported with regard to the human chromosomal localization of the structural gene for β glucuronidase (βGUS). Recently, the authors have established a human fibroblast strain with a balanced reciprocal X/7 translocation, 46,XX,t(X,7)(Xqter→ Xq21::7p22→7qter)(Xpter→Xq21::7p22→7pter)(Sauer et al., 1977). This strain has given the authors a unique opportunity to resolve the above controversy. The present communication describes the results obtained by using human mouse hybrids prepared from this fibroblast strain, which clearly indicate that human βGUS is localized on chromosome 7.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalCytogenetics and Cell Genetics
Volume17
Issue number5
StatePublished - 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology
  • Genetics

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