Somatic gene therapy for dyslipidemias

Maria Belalcazar, Lawrence Chan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Somatic gene transfer is a valuable tool for the in vivo evaluation of lipoprotein metabolism. It has been used to dissect metabolic pathways, to establish structure-function relationships of various gene products, and to evaluate conventional lipid-lowering and novel therapeutic genes for the treatment of lipoprotein disorders. In this article we review some general aspects of somatic gene therapy and the different vehicles used for the delivery of therapeutic genes. We highlight some recent advances in adenoviral vector development that make this vector an attractive system for clinical trials.

Original languageEnglish (US)
Pages (from-to)194-214
Number of pages21
JournalJournal of Laboratory and Clinical Medicine
Volume134
Issue number3
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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