Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis

A compensatory mechanism?

James R. Upp, Jin Ishizuka, Thom E. Lobe, Sirnivasan Rajaraman, Courtney Townsend, James C. Thompson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Two patients with nesidioblastosis, one with persistent hypoglycemia and another who was asymptomatic, underwent pancreatic resection. Dispersed pancreatic islets were prepared from each patient. Insulin secretion from cultured islet cells was increased and somatostatin decreased in the symptomatic patient compared with the asymptomatic patient. Immunocytochemistry showed increased somatostatin-containing cells in the asymptomatic patient. We hypothesize that this may be the mechanism by which some patients with nesidioblastosis maintain normal serum glucose levels.

Original languageEnglish (US)
Pages (from-to)1185-1186
Number of pages2
JournalJournal of Pediatric Surgery
Volume22
Issue number12
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Nesidioblastosis
Somatostatin
Islets of Langerhans
Somatostatin-Secreting Cells
Hypoglycemia
Cultured Cells
Immunohistochemistry
Insulin
Glucose
Serum

Keywords

  • Beckwith-Wiedemann syndrome
  • hypoglycemia
  • insulin
  • Islets of Langerhans
  • nesiodioblastosis
  • somatostatin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis : A compensatory mechanism? / Upp, James R.; Ishizuka, Jin; Lobe, Thom E.; Rajaraman, Sirnivasan; Townsend, Courtney; Thompson, James C.

In: Journal of Pediatric Surgery, Vol. 22, No. 12, 1987, p. 1185-1186.

Research output: Contribution to journalArticle

Upp, James R. ; Ishizuka, Jin ; Lobe, Thom E. ; Rajaraman, Sirnivasan ; Townsend, Courtney ; Thompson, James C. / Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis : A compensatory mechanism?. In: Journal of Pediatric Surgery. 1987 ; Vol. 22, No. 12. pp. 1185-1186.
@article{89983b7942464511b32b05daa84ee27c,
title = "Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis: A compensatory mechanism?",
abstract = "Two patients with nesidioblastosis, one with persistent hypoglycemia and another who was asymptomatic, underwent pancreatic resection. Dispersed pancreatic islets were prepared from each patient. Insulin secretion from cultured islet cells was increased and somatostatin decreased in the symptomatic patient compared with the asymptomatic patient. Immunocytochemistry showed increased somatostatin-containing cells in the asymptomatic patient. We hypothesize that this may be the mechanism by which some patients with nesidioblastosis maintain normal serum glucose levels.",
keywords = "Beckwith-Wiedemann syndrome, hypoglycemia, insulin, Islets of Langerhans, nesiodioblastosis, somatostatin",
author = "Upp, {James R.} and Jin Ishizuka and Lobe, {Thom E.} and Sirnivasan Rajaraman and Courtney Townsend and Thompson, {James C.}",
year = "1987",
doi = "10.1016/S0022-3468(87)80734-0",
language = "English (US)",
volume = "22",
pages = "1185--1186",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "12",

}

TY - JOUR

T1 - Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis

T2 - A compensatory mechanism?

AU - Upp, James R.

AU - Ishizuka, Jin

AU - Lobe, Thom E.

AU - Rajaraman, Sirnivasan

AU - Townsend, Courtney

AU - Thompson, James C.

PY - 1987

Y1 - 1987

N2 - Two patients with nesidioblastosis, one with persistent hypoglycemia and another who was asymptomatic, underwent pancreatic resection. Dispersed pancreatic islets were prepared from each patient. Insulin secretion from cultured islet cells was increased and somatostatin decreased in the symptomatic patient compared with the asymptomatic patient. Immunocytochemistry showed increased somatostatin-containing cells in the asymptomatic patient. We hypothesize that this may be the mechanism by which some patients with nesidioblastosis maintain normal serum glucose levels.

AB - Two patients with nesidioblastosis, one with persistent hypoglycemia and another who was asymptomatic, underwent pancreatic resection. Dispersed pancreatic islets were prepared from each patient. Insulin secretion from cultured islet cells was increased and somatostatin decreased in the symptomatic patient compared with the asymptomatic patient. Immunocytochemistry showed increased somatostatin-containing cells in the asymptomatic patient. We hypothesize that this may be the mechanism by which some patients with nesidioblastosis maintain normal serum glucose levels.

KW - Beckwith-Wiedemann syndrome

KW - hypoglycemia

KW - insulin

KW - Islets of Langerhans

KW - nesiodioblastosis

KW - somatostatin

UR - http://www.scopus.com/inward/record.url?scp=0023583104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023583104&partnerID=8YFLogxK

U2 - 10.1016/S0022-3468(87)80734-0

DO - 10.1016/S0022-3468(87)80734-0

M3 - Article

VL - 22

SP - 1185

EP - 1186

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 12

ER -