Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis: A compensatory mechanism?

James R. Upp, Jin Ishizuka, Thom E. Lobe, Sirnivasan Rajaraman, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Two patients with nesidioblastosis, one with persistent hypoglycemia and another who was asymptomatic, underwent pancreatic resection. Dispersed pancreatic islets were prepared from each patient. Insulin secretion from cultured islet cells was increased and somatostatin decreased in the symptomatic patient compared with the asymptomatic patient. Immunocytochemistry showed increased somatostatin-containing cells in the asymptomatic patient. We hypothesize that this may be the mechanism by which some patients with nesidioblastosis maintain normal serum glucose levels.

Original languageEnglish (US)
Pages (from-to)1185-1186
Number of pages2
JournalJournal of Pediatric Surgery
Volume22
Issue number12
DOIs
StatePublished - Dec 1987
Externally publishedYes

Keywords

  • Beckwith-Wiedemann syndrome
  • Islets of Langerhans
  • hypoglycemia
  • insulin
  • nesiodioblastosis
  • somatostatin

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis: A compensatory mechanism?'. Together they form a unique fingerprint.

  • Cite this