Spaceflight and spaceflight analogue induced responses in gram positive bacteria

Sarah L. Castro, David Niesel, Jennifer Barrila, C. Mark Ott

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The potential alterations in the disease-associated characteristics of Gram positive organisms during spaceflight missions are of great importance for future human exploration efforts. Gram positive organisms, especially Staphylococcus species, are the most prevalent species isolated from the air and surfaces of spacecraft vehicles. The frequent isolation of the opportunistic pathogen, Staphylococcus aureus, from the environment of the International Space Station (ISS) is not unexpected, as 30-50 % of healthy adults on Earth are colonized with this organism. Passage of these organisms between crewmembers is common as demonstrated by a genetic comparison of S. aureus strains isolated from crewmembers aboard the Mir space station. Microbial monitoring also indicated the presence of Streptococcus species aboard the Russian space station Mir and from air samples collected during Space Shuttle missions. While S. pneumoniae has not been isolated from spacecraft or from a crewmember after flight, this opportunistic bacterium has been isolated after nasopharyngeal sampling from a shuttle crewmember immediately before flight. As opportunistic pathogens, such as S. aureus and S. pneumoniae, are likely to be carried as part of the normal flora of a crew and may exploit a declining immune system, understanding the mechanisms behind the disease causing potential of Gram positive organisms has tremendous implications for the spaceflight crew, as well as advancing our knowledge of disease-causing mechanisms on Earth.

Original languageEnglish (US)
Title of host publicationEffect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms
PublisherSpringer New York
Pages283-296
Number of pages14
ISBN (Electronic)9781493932771
ISBN (Print)9781493932764
DOIs
StatePublished - Jan 1 2016

Fingerprint

Space Flight
Gram-Positive Bacteria
organisms
Spacecraft
bacteria
analogs
Mir space station
Staphylococcus aureus
pneumonia
Air
staphylococcus
pathogens
crews
Staphylococcal Pneumonia
Streptococcus
Staphylococcus
spacecraft
Space Shuttle missions
flight
Immune System

Keywords

  • Gram positive bacteria
  • Low-shear modeled microgravity
  • Rotating wall vessel bioreactor
  • Spaceflight
  • Spaceflight analogue
  • Staphylococcus aureus
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Physics and Astronomy(all)

Cite this

Castro, S. L., Niesel, D., Barrila, J., & Ott, C. M. (2016). Spaceflight and spaceflight analogue induced responses in gram positive bacteria. In Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms (pp. 283-296). Springer New York. https://doi.org/10.1007/978-1-4939-3277-1_14

Spaceflight and spaceflight analogue induced responses in gram positive bacteria. / Castro, Sarah L.; Niesel, David; Barrila, Jennifer; Ott, C. Mark.

Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, 2016. p. 283-296.

Research output: Chapter in Book/Report/Conference proceedingChapter

Castro, SL, Niesel, D, Barrila, J & Ott, CM 2016, Spaceflight and spaceflight analogue induced responses in gram positive bacteria. in Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, pp. 283-296. https://doi.org/10.1007/978-1-4939-3277-1_14
Castro SL, Niesel D, Barrila J, Ott CM. Spaceflight and spaceflight analogue induced responses in gram positive bacteria. In Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York. 2016. p. 283-296 https://doi.org/10.1007/978-1-4939-3277-1_14
Castro, Sarah L. ; Niesel, David ; Barrila, Jennifer ; Ott, C. Mark. / Spaceflight and spaceflight analogue induced responses in gram positive bacteria. Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells: Novel Insights into Disease Mechanisms. Springer New York, 2016. pp. 283-296
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