Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Ziad A. Memish; Ahmad Alsahly; Malak al Masri; Gary L. Heil; Benjamin D. Anderson; Malik Peiris; Salah Uddin Khan; Gregory C. Gray

doi:10.1111/irv.12287

Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Ziad A. Memish, Ahmad Alsahly, Malak al Masri, Gary L. Heil, Benjamin D. Anderson, Malik Peiris, Salah Uddin Khan, Gregory C. Gray

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.

Original language	English (US)
Pages (from-to)	64-67
Number of pages	4
Journal	Influenza and other respiratory viruses
Volume	9
Issue number	2
DOIs	https://doi.org/10.1111/irv.12287
State	Published - Mar 1 2015
Externally published	Yes

Keywords

Antibody
Kingdom of Saudi Arabia
MERS-CoV
Pseudoparticle virus neutralization assays

ASJC Scopus subject areas

Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1111/irv.12287

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abstract = "Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.",

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AU - Memish, Ziad A.

AU - Alsahly, Ahmad

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AU - Heil, Gary L.

AU - Anderson, Benjamin D.

AU - Peiris, Malik

AU - Khan, Salah Uddin

AU - Gray, Gregory C.

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Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Abstract

Keywords

ASJC Scopus subject areas

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