Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Ziad A. Memish; Ahmad Alsahly; Malak al Masri; Gary L. Heil; Benjamin D. Anderson; Malik Peiris; Salah Uddin Khan; Gregory C. Gray

doi:10.1111/irv.12287

Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Ziad A. Memish
, Ahmad Alsahly
, Malak al Masri
, Gary L. Heil
, Benjamin D. Anderson
, Malik Peiris
, Salah Uddin Khan
, Gregory C. Gray

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.

Original language	English (US)
Pages (from-to)	64-67
Number of pages	4
Journal	Influenza and other respiratory viruses
Volume	9
Issue number	2
DOIs	https://doi.org/10.1111/irv.12287
State	Published - Mar 1 2015
Externally published	Yes

Keywords

Antibody
Kingdom of Saudi Arabia
MERS-CoV
Pseudoparticle virus neutralization assays

ASJC Scopus subject areas

Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1111/irv.12287

Cite this

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title = "Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012",

abstract = "Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17\% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.",

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doi = "10.1111/irv.12287",

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AU - Memish, Ziad A.

AU - Alsahly, Ahmad

AU - Masri, Malak al

AU - Heil, Gary L.

AU - Anderson, Benjamin D.

AU - Peiris, Malik

AU - Khan, Salah Uddin

AU - Gray, Gregory C.

PY - 2015/3/1

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AB - Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.

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KW - Kingdom of Saudi Arabia

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Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Abstract

Keywords

ASJC Scopus subject areas

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