Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption

Erica L. McGrath, Junling Gao, Yong Fang Kuo, Tiffany J. Dunn, Moniqua J. Ray, Kelly T. Dineley, Kathryn A. Cunningham, Bhupendra S. Kaphalia, Ping Wu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Chronic alcohol abuse results in alcohol-related neurodegeneration, and critical gaps in our knowledge hinder therapeutic development. Neural stem cells (NSCs) are a subpopulation of cells within the adult brain that contribute to brain maintenance and recovery. While it is known that alcohol alters NSCs, little is known about how NSC response to alcohol is related to sex, brain region, and stage of differentiation. Understanding these relationships will aid in therapeutic development. Here, we used an inducible transgenic mouse model to track the stages of differentiation of adult endogenous NSCs and observed distinct NSC behaviors in three brain regions (subventricular zone, subgranular zone, and tanycyte layer) after long-term alcohol consumption. Particularly, chronic alcohol consumption profoundly affected the survival of NSCs in the subventricular zone and altered NSC differentiation in all three regions. Significant differences between male and female mice were further discovered. Wu and colleagues demonstrate that adult endogenous neural stem cells in three key brain regions have individual responses to alcohol consumption. Further, they show that these regional changes are affected by the sex of mice.

Original languageEnglish (US)
Pages (from-to)1916-1930
Number of pages15
JournalStem Cell Reports
Issue number6
StatePublished - Dec 12 2017


  • chronic alcohol
  • neural stem cell
  • neuronal differentiation
  • sex differences
  • subgranular zone
  • subventricular zone
  • tanycyte

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption'. Together they form a unique fingerprint.

Cite this