Spatial variation of Yersinia pestis from Yunnan Province of China

Zhikai Zhang, Rong Hai, Zhizhong Song, Lianxu Xia, Yun Liang, Hong Cai, Ying Liang, Xiaona Shen, Enmin Zhang, Jianguo Xu, Dongzheng Yu, Xue Jie Yu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Yunnan Province of China is considered the site of origin for modern plague. We analyzed the genotypes of eight Yersinia pestis strains isolated from three counties in Yunnan Province by pulse field gel electrophoresis (PFGE). PFGE showed that strains isolated from the same site were identical regardless of hosts or year of isolation. However, Y pestis strains isolated from geographically distinct loci were genetically divergent. Whole genome sequences of two strains from two foci in Yunnan showed that the genetic variation of Y pestis strains was caused by genome rearrangement. We concluded that Y pestis strains in each epidemic focus in Yunnan were a clonal population and selected by host environments. The genomic variability of the Y pestis strains from different foci were caused by genome rearrangement, which may provide a positive selective advantage for Y. pestis to adapt to its host environments.

Original languageEnglish (US)
Pages (from-to)714-717
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume81
Issue number4
DOIs
StatePublished - Oct 2009

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Yersinia pestis
China
Genome
Electrophoresis
Gels
Plague
Genotype
Population

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Spatial variation of Yersinia pestis from Yunnan Province of China. / Zhang, Zhikai; Hai, Rong; Song, Zhizhong; Xia, Lianxu; Liang, Yun; Cai, Hong; Liang, Ying; Shen, Xiaona; Zhang, Enmin; Xu, Jianguo; Yu, Dongzheng; Yu, Xue Jie.

In: American Journal of Tropical Medicine and Hygiene, Vol. 81, No. 4, 10.2009, p. 714-717.

Research output: Contribution to journalArticle

Zhang, Z, Hai, R, Song, Z, Xia, L, Liang, Y, Cai, H, Liang, Y, Shen, X, Zhang, E, Xu, J, Yu, D & Yu, XJ 2009, 'Spatial variation of Yersinia pestis from Yunnan Province of China', American Journal of Tropical Medicine and Hygiene, vol. 81, no. 4, pp. 714-717. https://doi.org/10.4269/ajtmh.2009.09-0174
Zhang, Zhikai ; Hai, Rong ; Song, Zhizhong ; Xia, Lianxu ; Liang, Yun ; Cai, Hong ; Liang, Ying ; Shen, Xiaona ; Zhang, Enmin ; Xu, Jianguo ; Yu, Dongzheng ; Yu, Xue Jie. / Spatial variation of Yersinia pestis from Yunnan Province of China. In: American Journal of Tropical Medicine and Hygiene. 2009 ; Vol. 81, No. 4. pp. 714-717.
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