Abstract
Yunnan Province of China is considered the site of origin for modern plague. We analyzed the genotypes of eight Yersinia pestis strains isolated from three counties in Yunnan Province by pulse field gel electrophoresis (PFGE). PFGE showed that strains isolated from the same site were identical regardless of hosts or year of isolation. However, Y pestis strains isolated from geographically distinct loci were genetically divergent. Whole genome sequences of two strains from two foci in Yunnan showed that the genetic variation of Y pestis strains was caused by genome rearrangement. We concluded that Y pestis strains in each epidemic focus in Yunnan were a clonal population and selected by host environments. The genomic variability of the Y pestis strains from different foci were caused by genome rearrangement, which may provide a positive selective advantage for Y. pestis to adapt to its host environments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 714-717 |
| Number of pages | 4 |
| Journal | American Journal of Tropical Medicine and Hygiene |
| Volume | 81 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2009 |
Fingerprint
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
- Virology
Cite this
Spatial variation of Yersinia pestis from Yunnan Province of China. / Zhang, Zhikai; Hai, Rong; Song, Zhizhong; Xia, Lianxu; Liang, Yun; Cai, Hong; Liang, Ying; Shen, Xiaona; Zhang, Enmin; Xu, Jianguo; Yu, Dongzheng; Yu, Xue Jie.
In: American Journal of Tropical Medicine and Hygiene, Vol. 81, No. 4, 10.2009, p. 714-717.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spatial variation of Yersinia pestis from Yunnan Province of China
AU - Zhang, Zhikai
AU - Hai, Rong
AU - Song, Zhizhong
AU - Xia, Lianxu
AU - Liang, Yun
AU - Cai, Hong
AU - Liang, Ying
AU - Shen, Xiaona
AU - Zhang, Enmin
AU - Xu, Jianguo
AU - Yu, Dongzheng
AU - Yu, Xue Jie
PY - 2009/10
Y1 - 2009/10
N2 - Yunnan Province of China is considered the site of origin for modern plague. We analyzed the genotypes of eight Yersinia pestis strains isolated from three counties in Yunnan Province by pulse field gel electrophoresis (PFGE). PFGE showed that strains isolated from the same site were identical regardless of hosts or year of isolation. However, Y pestis strains isolated from geographically distinct loci were genetically divergent. Whole genome sequences of two strains from two foci in Yunnan showed that the genetic variation of Y pestis strains was caused by genome rearrangement. We concluded that Y pestis strains in each epidemic focus in Yunnan were a clonal population and selected by host environments. The genomic variability of the Y pestis strains from different foci were caused by genome rearrangement, which may provide a positive selective advantage for Y. pestis to adapt to its host environments.
AB - Yunnan Province of China is considered the site of origin for modern plague. We analyzed the genotypes of eight Yersinia pestis strains isolated from three counties in Yunnan Province by pulse field gel electrophoresis (PFGE). PFGE showed that strains isolated from the same site were identical regardless of hosts or year of isolation. However, Y pestis strains isolated from geographically distinct loci were genetically divergent. Whole genome sequences of two strains from two foci in Yunnan showed that the genetic variation of Y pestis strains was caused by genome rearrangement. We concluded that Y pestis strains in each epidemic focus in Yunnan were a clonal population and selected by host environments. The genomic variability of the Y pestis strains from different foci were caused by genome rearrangement, which may provide a positive selective advantage for Y. pestis to adapt to its host environments.
UR - http://www.scopus.com/inward/record.url?scp=70349741144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349741144&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2009.09-0174
DO - 10.4269/ajtmh.2009.09-0174
M3 - Article
VL - 81
SP - 714
EP - 717
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 4
ER -